Ethyl 4-bromo-1H-pyrrole-2-carboxylate
- CAS No.
- 433267-55-1
- Chemical Name:
- Ethyl 4-bromo-1H-pyrrole-2-carboxylate
- Synonyms
- EOS-60603;RARECHEM AL BI 1264;Ethyl 4-bromopyrrole-2-carboxylate;Ethyl 4-bromopyrrole-2-carboxylate 97%;Ethyl 4-bromo-1H-pyrrole-2-carboxylate;433267-55-1;4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester;1H-Pyrrole-2-carboxylic acid, 4-broMo-, ethyl ester;ENCHEM 4-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID ETHYL ESTER 433267-55-1
- CBNumber:
- CB7384280
- Molecular Formula:
- C7H8BrNO2
- Molecular Weight:
- 218.05
- MDL Number:
- MFCD06205071
- MOL File:
- 433267-55-1.mol
- MSDS File:
- SDS
| Melting point | 58-63°C |
|---|---|
| Boiling point | 301.7±22.0 °C(Predicted) |
| Density | 1.576±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | 13.58±0.50(Predicted) |
| Appearance | White to off-white Solid |
| InChI | 1S/C7H8BrNO2/c1-2-11-7(10)6-3-5(8)4-9-6/h3-4,9H,2H2,1H3 |
| InChIKey | ZNKYCJKUHXQUJQ-UHFFFAOYSA-N |
| SMILES | CCOC(=O)c1cc(Br)c[nH]1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
Ethyl 4-bromo-1H-pyrrole-2-carboxylate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 729787 | Ethyl 4-bromopyrrole-2-carboxylate 97% | 433267-55-1 | 1g | $70 | 2026-04-30 | Buy |
| Synthonix | E23668 | Ethyl 4-bromo-1H-pyrrole-2-carboxylate 97% | 433267-55-1 | 250mg | $14 | 2026-05-06 | Buy |
| Synthonix | E23668 | Ethyl 4-bromo-1H-pyrrole-2-carboxylate 97% | 433267-55-1 | 1g | $20 | 2026-05-06 | Buy |
| Synthonix | E23668 | Ethyl 4-bromo-1H-pyrrole-2-carboxylate 97% | 433267-55-1 | 5g | $30 | 2026-05-06 | Buy |
| Synthonix | E23668 | Ethyl 4-bromo-1H-pyrrole-2-carboxylate 97% | 433267-55-1 | 25g | $100 | 2026-05-06 | Buy |
Ethyl 4-bromo-1H-pyrrole-2-carboxylate Chemical Properties, Uses, Production
Application
Ethyl 4-bromo-1H-pyrrole-2-carboxylic acid ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.
Synthesis
72652-32-5
141-52-6
433267-55-1
Anhydrous ethanol (950.0 kg) was added to a 3000 L glass-lined reactor followed by 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone (342.7 kg), keeping the reaction temperature at 20-30 °C. The reaction mixture was cooled to 0-5°C over about 2 hours. At this temperature, 21% sodium ethanol solution (36.4 kg) was slowly added dropwise over 1-1.5 hours. Upon completion of the dropwise addition, the reaction mixture was warmed to 25-30 °C and monitored to ensure that the content of 1-(4-bromo-1H-pyrrol-2-yl)-2,2,2-trichloroacetophenone was reduced to <1.0%. Subsequently, the reaction mixture was concentrated at a temperature not exceeding 50 °C until the remaining volume was 1.3-1.4 times the original volume. The concentrate was cooled to 25-30 °C and quenched by slowly pouring it into cold water (3427.0 kg) over about 2 hours. After quenching, the mixture was stirred at 0-5°C for about 2 hours to promote crystallization. After crystallization was completed, the solid product was separated by filtration and the filter cake was washed with cold water. Finally, the resulting solid was dried at 30-40 °C for 40-45 h to afford ethyl 4-bromo-1H-pyrrole-2-carboxylate (234.3 kg) with 99.9% purity and 91.3% yield.
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 12, p. 6001 - 6011
[2] Patent: WO2015/31562, 2015, A1. Location in patent: Page/Page column 19; 25
Ethyl 4-bromo-1H-pyrrole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu jingzhihuacheng Chemical Technology Co., Ltd. | 028-37664989 15900794981 | 873239557@qq.com | China | 1050 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 659 | 62 |
View Latest Price from Ethyl 4-bromo-1H-pyrrole-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
433267-55-1
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- ETHYL 4-BROMO-1H-PYRROLE-2-CARBOXYLATE
433267-55-1
- $1.00
- 95%
- Career Henan Chemical Co
