5-Nitroquinoxaline
- CAS No.
- 18514-76-6
- Chemical Name:
- 5-Nitroquinoxaline
- Synonyms
- 5-nitro-quinoxalin;5-Nitroquinoxaline;Quinoxaline, 5-nitro-
- CBNumber:
- CB7436677
- Molecular Formula:
- C8H5N3O2
- Molecular Weight:
- 175.14
- MDL Number:
- MFCD01684951
- MOL File:
- 18514-76-6.mol
- MSDS File:
- SDS
| Melting point | 90-92℃ |
|---|---|
| Boiling point | 329℃ |
| Density | 1.437 |
| Flash point | 153℃ |
| storage temp. | 2-8°C |
| pka | -2.09±0.30(Predicted) |
| FDA UNII | YDZ6TV2TNM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-Nitroquinoxaline price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 085575 | 5-Nitroquinoxaline | 18514-76-6 | 250.00mg | $43 | 2026-05-18 | Buy |
| Matrix Scientific | 085575 | 5-Nitroquinoxaline | 18514-76-6 | 1.00g | $113 | 2026-05-18 | Buy |
| Matrix Scientific | 085575 | 5-Nitroquinoxaline | 18514-76-6 | 5.00g | $389 | 2026-05-18 | Buy |
| Synthonix | N47643 | 5-Nitroquinoxaline 95+% | 18514-76-6 | 100mg | $90 | 2026-05-06 | Buy |
| Synthonix | N47643 | 5-Nitroquinoxaline 95+% | 18514-76-6 | 250mg | $130 | 2026-05-06 | Buy |
5-Nitroquinoxaline Chemical Properties, Uses, Production
Synthesis
131543-46-9
3694-52-8
18514-76-6
The general procedure for the synthesis of 5-nitroquinoxaline from the compound (CAS:131543-46-9) and 3-nitro-o-phenylenediamine was as follows: general method 108: Acetaldehyde (40% aqueous solution, 1.43 mL, 31.3 mmol) was added to a solution of 3-nitro-o-phenylenediamine (600 mg, 3.9 mmol) in ethanol (15 mL). The reaction mixture was heated to reflux at 85 °C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, the residue was diluted with an appropriate amount of water and the aqueous phase was extracted with dichloromethane (DCM). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography using dichloromethane/methanol (99:1, v/v) as eluent to afford the target compound 5-nitroquinoxaline (666 mg, 97% yield). Molecular weight (MW): 175.15. High performance liquid chromatography-mass spectrometry (HPLC-MS, Method C) analysis: [m/z]: 176.
References
[1] Patent: US2012/214803, 2012, A1. Location in patent: Page/Page column 174
[2] Patent: WO2016/77240, 2016, A2. Location in patent: Page/Page column 68
[3] Patent: CN107805223, 2018, A. Location in patent: Paragraph 0019
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 6707 - 6723
[5] Patent: EP1147083, 2004, B1. Location in patent: Page 38
5-Nitroquinoxaline Preparation Products And Raw materials
Raw materials
Preparation Products
5-Nitroquinoxaline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1995 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Chiral bio-compound co., Ltd. | 021-5068 3667/17749785980/1029026415; 17749785980 | 1029026415@qq.com | China | 4501 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lanzhou Kangyuxin Biotechnology Co., Ltd. | 0943-8293106 | sales@kyxpharma.com | China | 3552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 |
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