1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid
- CAS No.
- 305381-67-3
- Chemical Name:
- 1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid
- Synonyms
- 1,2,3-Propanetriol,1,8-diacetate;1-methylbenzotriazole-5-carboxylic acid;1-METHYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1H-Benzotriazole-5-carboxylicacid, 1-Methyl-;1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid;1-methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid;1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid - [M86437]
- CBNumber:
- CB7459139
- Molecular Formula:
- C8H7N3O2
- Molecular Weight:
- 177.16
- MDL Number:
- MFCD03086163
- MOL File:
- 305381-67-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P301+P312-P302+P352-P304+P340-P361+P364 |
| Hazard Codes | Xi |
| Risk Statements | 41 |
| Hazard Note | Harmful |
| HS Code | 2933998090 |
1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR23371 | 1-Methyl-1H-benzotriazole-5-carboxylic acid ≥95% | 305381-67-3 | 250mg | $52 | 2026-06-04 | Buy |
| Matrix Scientific | 304644 | 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid | 305381-67-3 | 250.00mg | $47 | 2026-05-19 | Buy |
| Matrix Scientific | 304644 | 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid | 305381-67-3 | 1.00g | $102 | 2026-05-19 | Buy |
| Matrix Scientific | 304644 | 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid | 305381-67-3 | 5.00g | $454 | 2026-05-19 | Buy |
| Synthonix | M86437 | 1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid 97% | 305381-67-3 | 100mg | $31 | 2026-05-06 | Buy |
1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid Chemical Properties, Uses, Production
Application
1-Methyl-1,2,3-benzotriazole-5-carboxylic acid is an organic intermediate that can be prepared from 4-amino-3-nitrobenzoic acid as a raw material. 4-amino-3-nitrobenzoic acid is then prepared, followed by methylation to obtain methyl 4-methylamino-3-nitrobenzoate, reduction of the nitro group to obtain methyl 4-methylamino-3-aminobenzoate, cyclization to obtain methyl 4-methylamino-3-aminobenzoate, and finally hydrolysis of the methyl ester to obtain 1-methyl-1,2,3-benzotriazole-5-carboxylic acid.
Synthesis
The synthesis of 1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid is carried out as follows:
To a stirred suspension of the diamine 280 (1.08g; 6.48mmol) (or any other oarylenediamine) in water (25 mL) at 0°C, concentrated HCl (5.4 mL) was added drop wise followed by slow addition of a solution of NaNO2 (643mg; 9.3mmol) in water (10 mL). The reaction mixture was stirred at 0°C for 2h and then was allowed to warm up to 10°C over 4h; neutralized with a solution of KOH (5.6 g) in water (30mL) (final pH = 6); concentrated and purified by preparative HPLC in reverse phase mode (column aquasil C-18, elution 5% to 95% MeOH in water), to afford the title compound 284 (211 mg; 18% yield). 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid (284), yield (211 mg; 18%). 1HNMR: (400.2 MHz, DMSO) δ (ppm): 8.35 (s; 1H); 8.08 (dd, J= 1.4, 8.6 Hz; 1H); 7.75 (d, J= 1.4 Hz; 1H); 4.03 (s, 3H). MS: calc: 177.1; found: 178.1 (M+H).
1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Pharmsynth Pharmaceutical (Chengdu) Technology Co.,LTD | 15528092102 | Pharmsynth@hotmail.com | China | 116 | 60 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| PingHeAnKang Pharmaceutical Co., Ltd. | 18086832706 | phakzjtxs@phak.cn | China | 138 | 58 |
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