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2-PHENYL-5-OXAZOLONE

2-PHENYL-5-OXAZOLONE Structure
2-PHENYL-5-OXAZOLONE structure
CAS No.
1199-01-5
Chemical Name:
2-PHENYL-5-OXAZOLONE
Synonyms
Phenyloxazolone;2-phenyloxazolone;2-PHENYL-5-OXAZOLONE;2-phenyl-5(4h)-oxazolon;2-Phenyl-5(4H)-oxazolone;2-PHENYL-2-OXAZOLIN-5-ONE;2-PHENYL-4H-OXAZOL-5-ONE;2-Phenyl-2-oxazoline-5-one;2-phenyl-4H-1,3-oxazol-5-one
CBNumber:
CB7469864
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MDL Number:
MFCD00014517
MOL File:
1199-01-5.mol
MSDS File:
SDS
Last updated:2026-05-28 02:50:17
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2-PHENYL-5-OXAZOLONE Properties

Melting point 89-92°C
Boiling point 248.1±23.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in most common organic solvents.
pka 2.56±0.20(Predicted)
Appearance Off-white to light yellow Solid
Sensitive Air Sensitive
BRN 128465
EPA Substance Registry System 5(4H)-Oxazolone, 2-phenyl- (1199-01-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H312-H315-H318-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Safety Statements  22-24/25
TSCA  TSCA listed
NFPA 704
1
0 0

2-PHENYL-5-OXAZOLONE price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S554243 2-PHENYL-2-OXAZOLIN-5-ONE AldrichCPR 1199-01-5 1 unit $152 2026-04-30 Buy
Sigma-Aldrich S301604 2-PHENYL-4H-OXAZOL-5-ONE AldrichCPR 1199-01-5 1 unit $32.7 2026-04-30 Buy
Sigma-Aldrich S554243 2-PHENYL-2-OXAZOLIN-5-ONE Aldrich 1199-01-5 250mg $139 2024-03-01 Buy
Sigma-Aldrich S301604 2-PHENYL-4H-OXAZOL-5-ONE Aldrich 1199-01-5 25mg $29.8 2024-03-01 Buy
AstaTech 65136 2-PHENYL-4H-OXAZOL-5-ONE 95% 1199-01-5 0.25G $39 2026-04-30 Buy
Product number Packaging Price Buy
S554243 1 unit $152 Buy
S301604 1 unit $32.7 Buy
S554243 250mg $139 Buy
S301604 25mg $29.8 Buy
65136 0.25G $39 Buy

2-PHENYL-5-OXAZOLONE Chemical Properties,Uses,Production

Uses

2-Phenyl-5-oxazolone is a reagent used as a masked glycine equivalent and for the formation of heterocyclic structures, it can be used to produce 4-benzylidene-2-phenyl-4H-oxazol-5-one.

Definition

ChEBI: A 1,3-oxazole having a phenyl substituent at the 2-position and an oxo group at the 5-position. Note that phenyloxazolone is commonly used as a synonym for 4-(ethoxymethylene)-2-phenyloxazol-5-one (PhOx).

Synthesis

Hippuric acid

495-69-2

2-PHENYL-5-OXAZOLONE

1199-01-5

The general procedure for the synthesis of 2-phenyl-5-azolone from equine uric acid was as follows: equine uric acid (5.0 g, 27.9 mmol) and EDCI-HCl (7.0 g, 36.3 mmol) were dissolved in dichloromethane (50 mL) and stirred for 45 min at room temperature under nitrogen protection. Upon completion of the reaction, the reaction was quenched with water. The organic layer was separated and washed twice with water and once with brine sequentially, then dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated in vacuum to afford 2-phenyl-5-azolone as an off-white solid (4.1 g, 91% yield), which could be used in the next reaction without further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, 600 MHz, CDCl3) data of the product were as follows: δ 7.96 (dd, J = 5.2, 3.3 Hz, 2H), 7.55 (m, 1H), 7.46 (m, 2H), 4.38 (s, 2H). Nuclear magnetic resonance carbon spectroscopy (13C NMR, 151 MHz, CDCl3) data were as follows: δ 176.00, 163.54, 132.87, 129.09, 128.88, 128.66, 127.86, 125.94, 77.37, 77.16, 76.95, 55.04.

References

[1] Organic Letters, 2016, vol. 18, # 4, p. 696 - 699
[2] Patent: WO2017/147646, 2017, A1. Location in patent: Page/Page column 42; 43
[3] Synthesis, 1982, # 3, p. 191 - 193
[4] Synthetic Communications, 1980, vol. 10, # 10, p. 761 - 766
[5] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1145 - 1150

2-PHENYL-5-OXAZOLONE Preparation Products And Raw materials

Raw materials

Hippuric acid Dichloromethane n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride

Preparation Products

2-PHENYL-4-(2-QUINOLINYL)-1,3-OXAZOL-5(4H)-ONE 4-[(3-fluorophenyl)methylene]-2-phenyloxazol-5(4H)-one ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE

2-PHENYL-5-OXAZOLONE Suppliers

Global( 100)Suppliers
Supplier Tel Email Country ProdList Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
China Langchem Inc. 0086-21-58956006 China 7798 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791,13386096464 bzswkf@foxmail.com China 3916 50
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Supplier Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Shandong Xiya Chemical Co., Ltd 57
China Langchem Inc. 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai BeiZhuo Biotech Co., Ltd. 50
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58

View Lastest Price from 2-PHENYL-5-OXAZOLONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-PHENYL-5-OXAZOLONE pictures 2026-06-30 2-PHENYL-5-OXAZOLONE
1199-01-5
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-PHENYL-5-OXAZOLONE pictures 2019-12-31 2-PHENYL-5-OXAZOLONE
1199-01-5
 $6.60 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
2-PHENYL-5-OXAZOLONE pictures 2019-11-08 2-PHENYL-5-OXAZOLONE
1199-01-5
 1g 98%min 20kg/month Nanjing jinheyou Trading Co., Ltd.

2-PHENYL-5-OXAZOLONE Spectrum

2-PHENYL-5-OXAZOLONE(1199-01-5)1HNMR

1199-01-5(2-PHENYL-5-OXAZOLONE)Related Search:

2,4-Dihydro-5-methyl-2-(4-methylphenyl)-3H-pyrazol-3-one 2-PHENYL-5-OXAZOLONE 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE 4-Benzylidene-2-phenyl-4,5-dihydro-1,3-oxazol-5-one S-DIPHENYLCARBAZONE
Antipyrine METHAQUALONE 5-Oxo-1-phenyl-2-pyrazolin-3-carboxylic acid 4-BENZYL-2-PHENYL-2-OXAZOLINE-5-ONE 4-(2,4-DIMETHOXYBENZYLIDENE)-5-OXO-2-PHENYLOXAZOLINE
4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE 4-(3,4-METHYLENEDIOXYBENZAL)-2-PHENYL-5-OXAZOLONE,4-(3,4-METHYLENEDIOXYBENZYLIDENE)-2-PHENYL-5-OXAZOLONE 4-BENZAL-2-PHENYL-5-OXAZOLONE 4-METHYL-2-PHENYL-5-OXAZOLONE 4-METHYL-2-PHENYL-5-OXAZOLONE
AKOS BBS-00001160 AKOS BBS-00001159 AURORA 682

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2-phenyl-5(4h)-oxazolon 2-phenyloxazolone 2-PHENYL-5-OXAZOLONE 2-PHENYL-4H-OXAZOL-5-ONE 2-PHENYL-2-OXAZOLIN-5-ONE 2-Phenyl-2-oxazoline-5-one 2-Phenyl-5(4H)-oxazolone Phenyloxazolone 2-phenyl-4H-1,3-oxazol-5-one 1199-01-5