6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one
- CAS No.
- 727664-79-1
- Chemical Name:
- 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one
- Synonyms
- Thr101;NOX Inhibitor VII, Thr101;6-fluoro-2-o-tolylbenzo[d] isothiazol-3(2H)-one;6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one;6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one;1,2-Benzisothiazol-3(2H)-one, 6-fluoro-2-(2-methylphenyl)-
- CBNumber:
- CB74798131
- Molecular Formula:
- C14H10FNOS
- Molecular Weight:
- 259.3
- MDL Number:
- MOL File:
- 727664-79-1.mol
- MSDS File:
- SDS
| Boiling point | 397.9±52.0 °C(Predicted) |
|---|---|
| Density | 1.363±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 50mg/mL |
| form | Solid |
| pka | -2.59±0.20(Predicted) |
| color | Off-white to yellow |
| InChIKey | BUIZTXXZBDUOCR-UHFFFAOYSA-N |
| SMILES | Fc1cc2c(cc1)C(=O)N(S2)c3c(cccc3)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CEB66479 | 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | 727664-79-1 | 10mg | $250 | 2026-06-04 | Buy |
| Biosynth | CEB66479 | 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | 727664-79-1 | 5mg | $250 | 2026-06-04 | Buy |
| Biosynth | CEB66479 | 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | 727664-79-1 | 25mg | $370 | 2026-06-04 | Buy |
| Biosynth | CEB66479 | 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | 727664-79-1 | 50mg | $592 | 2026-06-04 | Buy |
| Biosynth | CEB66479 | 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | 727664-79-1 | 100mg | $948 | 2026-06-04 | Buy |
6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Chemical Properties, Uses, Production
Description
Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor.
Uses
Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1].
Definition
ChEBI: 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one is a member of benzothiazoles.
References
[1] Dahl R, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8. DOI:10.1021/jm101401a
6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 18696571988 | amy.lei@chemieliva.com | China | 1350 | 60 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Henan Dowon Chemical Technology Co., Ltd. | 16696119288 | 779113375@qq.com | China | 7401 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Changzhou Yourui Pharmaceutical Technology Co., Ltd | 18168818882 | 877458914@qq.com | China | 8663 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
