1-ADAMANTYL BROMOMETHYL KETONE
- CAS No.
- 5122-82-7
- Chemical Name:
- 1-ADAMANTYL BROMOMETHYL KETONE
- Synonyms
- AKOS BC-0476;AKOS BBS-00006527;IFLAB-BB F1928-0001;OTAVA-BB BB7020410089;LABOTEST-BB LT00077095;1-(BROMOACETYL)ADAMANTANE;Bromomethyl adamantly ketone;bromomethyl1-adamantylketone;Bromomethyl adamantyl ketone;ketone,1-adamantylbromomethyl
- CBNumber:
- CB7483000
- Molecular Formula:
- C12H17BrO
- Molecular Weight:
- 257.17
- MDL Number:
- MFCD00074740
- MOL File:
- 5122-82-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-Adamantyl bromomethyl ketone 97% | 149292 | 5g | $201 |
| 1-(Bromoacetyl)adamantane 98% | OR01669 | 1g | $25 |
| 1-(Bromoacetyl)adamantane 98% | OR01669 | 25g | $264 |
| 1-(1-Adamantyl)-2-bromoethanone | 065322 | 500.00mg | $95 |
| 1-(Adamantan-1-yl)-2-bromoethanone 98% | A93667 | 1g | $78 |
| More product size | |||
| Melting point | 76-79 °C (lit.) |
|---|---|
| Boiling point | 320.3±15.0 °C(Predicted) |
| Density | 1.439±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | 1S/C12H17BrO/c13-7-11(14)12-4-8-1-9(5-12)3-10(2-8)6-12/h8-10H,1-7H2/t8-,9+,10-,12- |
| InChIKey | KWCDIRFSULAMOC-GOCCLTDMSA-N |
| SMILES | BrCC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |
| CAS DataBase Reference | 5122-82-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36/37/39-27 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29142900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-ADAMANTYL BROMOMETHYL KETONE price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 149292 | 1-Adamantyl bromomethyl ketone 97% | 5122-82-7 | 5g | $201 | 2026-04-30 | Buy |
| Apolloscientific | OR01669 | 1-(Bromoacetyl)adamantane 98% | 5122-82-7 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR01669 | 1-(Bromoacetyl)adamantane 98% | 5122-82-7 | 25g | $264 | 2026-06-04 | Buy |
| Matrix Scientific | 065322 | 1-(1-Adamantyl)-2-bromoethanone | 5122-82-7 | 500.00mg | $95 | 2026-05-18 | Buy |
| Synthonix | A93667 | 1-(Adamantan-1-yl)-2-bromoethanone 98% | 5122-82-7 | 1g | $78 | 2026-05-06 | Buy |
1-ADAMANTYL BROMOMETHYL KETONE Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
1-Adamantyl bromomethyl ketone may be used in chemical synthesis studies.
Synthesis
1660-04-4
5122-82-7
The general procedure for the synthesis of 1-adamantyl bromomethyl ketone from 1-adamantyl methyl ketone was as follows: 1-adamantyl methyl ketone (1.0 equiv) was reacted with N-bromosuccinimide (NBS, 1.1 equiv) in a mixed solvent of petroleum ether and methanol at reflux for 2 h at 333 K. The reaction was carried out at 333 K for 2 h. The reaction was completed by filtration and purification with ethanol. Upon completion of the reaction, the resulting precipitate of 1-adamantyl bromomethyl ketone (1) was collected by filtration and purified by recrystallization with ethanol. Subsequently, the purified 1-adamantyl bromomethyl ketone (1) (0.51 g, 0.002 mol) was reacted with the corresponding carboxylic acid (1.5 equiv) in the presence of potassium carbonate (1.2 equiv) with stirring at room temperature in DMF (8 mL) for about 3 hours. The reaction process was monitored by thin layer chromatography (TLC). At the end of the reaction, the reaction mixture was slowly poured into ice-cooled water with continuous stirring for 10 min. The resulting solid product was separated by filtration, washed sequentially with distilled water, dried and further purified using acetone recrystallization [20]. All 1-adamantyl bromomethyl ketone derivatives were obtained in high yields and high purity. In addition, single crystal samples suitable for single crystal X-ray diffraction analysis were successfully obtained by incubation from different solvent systems. The chemical structures of the compounds were corroborated by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. The crystal structures of all compounds except compounds 2m and 2q were determined by single crystal X-ray diffraction analysis.
Purification Methods
Dissolve the ketone in Et2O, wash it with H2O, dry (MgSO4), evaporate and crystallise the residue from small volumes of MeOH. LACHRYMATORY. [Stetter & Rauscher Chem Ber 93 2054 1960.]
References
[1] Molecules, 2015, vol. 20, # 10, p. 18827 - 18846
[2] Patent: WO2016/131380, 2016, A1. Location in patent: Paragraph 358; 359
[3] Russian Journal of Organic Chemistry, 2015, vol. 51, # 2, p. 184 - 187
[4] Zh. Org. Khim., 2015, vol. 51, # 2, p. 196 - 199
[5] Chemische Berichte, 1960, vol. 93, p. 2054 - 2057
1-ADAMANTYL BROMOMETHYL KETONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 | 1015@dideu.com | China | 3861 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49890 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
View Lastest Price from 1-ADAMANTYL BROMOMETHYL KETONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1-Adamantyl bromomethyl ketone 97%
5122-82-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 1-ADAMANTYL BROMOMETHYL KETONE
5122-82-7
|
$1.00 | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- 1-Adamantyl bromomethyl ketone 97%
5122-82-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-ADAMANTYL BROMOMETHYL KETONE
5122-82-7
- $1.00
- 99%
- Career Henan Chemical Co
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