BIBP 3226
- CAS No.
- 159013-54-4
- Chemical Name:
- BIBP 3226
- Synonyms
- BIBP 3226 trifluoroa;BIBP 3226 trifluoroacetate;BIBP3226 trifluoroacetate salt Diphenylacetyl-D-Arg-4-hydroxybenzylamide trifluoroacetate salt;(2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide;Benzeneacetamide, N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-;N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamidetrifluoroacetate
- CBNumber:
- CB7497915
- Molecular Formula:
- C27H31N5O3
- Molecular Weight:
- 473.57
- MDL Number:
- MFCD00938562
- MOL File:
- 159013-54-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.24±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 1 mg/mL |
| pka | 9.71±0.15(Predicted) |
| form | A solid |
| Water Solubility | H2O: 1mg/mL |
| InChIKey | KUWBXRGRMQZCSS-HSZRJFAPSA-N |
| SMILES | NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c2ccccc2)C(=O)NCc3ccc(O)cc3 |
| FDA UNII | RG9766UGZ8 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
BIBP 3226 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B174 | BIBP 3226 | 159013-54-4 | 5mg | $949 | 2022-05-15 | Buy |
| Biosynth | JGA01354 | BIBP 3226 | 159013-54-4 | 5mg | $1456.9 | 2026-06-04 | Buy |
| Biosynth | JGA01354 | BIBP 3226 | 159013-54-4 | 10mg | $2027 | 2026-06-04 | Buy |
| Biosynth | JGA01354 | BIBP 3226 | 159013-54-4 | 25mg | $3800.5 | 2026-06-04 | Buy |
| Biosynth | JGA01354 | BIBP 3226 | 159013-54-4 | 50mg | $6081 | 2026-06-04 | Buy |
BIBP 3226 Chemical Properties, Uses, Production
Uses
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect[1][2].
Biological Activity
Mixed non-peptide neuropeptide Y Y 1 (NPY Y 1 ) and neuropeptide FF (NPFF) receptor antagonist (K i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y 1 , hNPFF 2 , rNPFF, rNPY Y 2 , rNPY Y 4 and rNPY Y 5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.
Biochem/physiol Actions
Selective non-peptide neuropeptide Y1 (NPY1) receptor antagonist.
in vivo
BIBP3226 (0.5, 5 μg; i.c.v.; male Wistar rats) induces an anxiogenic-like effect at the higher dose[1].
References
[1] Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. DOI:10.1038/sj.bjp.0704049
BIBP 3226 Preparation Products And Raw materials
Raw materials
Preparation Products
BIBP 3226 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
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