4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
- CAS No.
- 327036-89-5
- Chemical Name:
- 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
- Synonyms
- CS-568;NP 01139;TDZD-8/TDZD8;TDZD-8, >=98%;TDZD 8 - Bio-X ?;TDZD-8 (NP-01139);GSK-3β Inhibitor I;TDZD-8, 10 mM in DMSO;GSK-3InhibitorI,TDZD-8;Alitretinoin intermediate
- CBNumber:
- CB7501586
- Molecular Formula:
- C10H10N2O2S
- Molecular Weight:
- 222.26
- MDL Number:
- MFCD04973552
- MOL File:
- 327036-89-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| TDZD-8 ≥98% (HPLC), needles | T8325 | 5mg | $197 |
| GSK-3β Inhibitor I | 361540 | 5mg | $126 |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC) | B4436 | 5mg | $52 |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC) | B4436 | 25mg | $156 |
| TDZD-8 ≥98% | 16287 | 5mg | $68 |
| More product size | |||
| Melting point | 63-64.4 °C |
|---|---|
| Boiling point | 335.5±35.0 °C(Predicted) |
| Density | 1.375±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | needles |
| pka | -2.08±0.20(Predicted) |
| color | white |
| InChI | InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3 |
| InChIKey | JDSJDASOXWCHPN-UHFFFAOYSA-N |
| SMILES | S1C(=O)N(CC2=CC=CC=C2)C(=O)N1C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H334 | |||||||||
| Precautionary statements | P261-P342+P311 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T8325 | TDZD-8 ≥98% (HPLC), needles | 327036-89-5 | 5mg | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | 361540 | GSK-3β Inhibitor I | 327036-89-5 | 5mg | $126 | 2025-07-31 | Buy |
| TCI Chemical | B4436 | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC) | 327036-89-5 | 5mg | $52 | 2026-04-30 | Buy |
| TCI Chemical | B4436 | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione >98.0%(HPLC) | 327036-89-5 | 25mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 16287 | TDZD-8 ≥98% | 327036-89-5 | 5mg | $68 | 2026-04-30 | Buy |
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
Uses
Glycogen Synthase Kinase-3 is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selectiv
Definition
ChEBI: TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.
General Description
A cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50 = 2 μM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 μM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 μM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
Biological Activity
tdzd-8 is an inhibitor of glycogen synthase kinase-3β (gsk-3β) with ic50 value of 1.4μm [1].tdzd-8 is a potent inhibitor of gsk-3β. it is found to act as a noncompetitive inhibitor of atp binding. tdzd-8 is selective against gsk-3β over other protein kinases including pka, casein kinase ii and cyclin dependent kinase 1 (cdk-1/cyclin b). however, it is also reported that tdzd-8 can inhibit the protein kinase c isoforms pkcβi and pkcδ with ic50 values of 1.4μm and 1.1μm, respectively [1, 2].in cellular assay, tdzd-8 is found to decrease pdt-induced necrosis of neurons and decrease pdt-induced apoptosis of glial cells through inhibiting gsk-3β as well as pkc. besides that, tdzd-8 also has anti-leukemia activity in many primary human leukemia cells. it is probably due to its inhibition of pkc and flt3 [3].
Biochem/physiol Actions
Primary TargetGsk-3β
storage
Store at -20°C
References
[1] komandirov m a, knyazeva e a, fedorenko y p, et al. on the role of phosphatidylinositol 3-kinase, protein kinase b/akt, and glycogen synthase kinase-3β in photodynamic injury of crayfish neurons and glial cells. journal of molecular neuroscience, 2011, 45(2): 229-235.
[2] martinez a, alonso m, castro a, et al. first non-atp competitive glycogen synthase kinase 3 β (gsk-3β) inhibitors: thiadiazolidinones (tdzd) as potential drugs for the treatment of alzheimer's disease. journal of medicinal chemistry, 2002, 45(6): 1292-1299.
[3] guzman m l, li x, corbett c a, et al. rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1, 2, 4-thiadiazolidine, 3, 5 dione (tdzd-8). blood, 2007, 110(13): 4436-4444.
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 | contact@trustwe.com | China | 5742 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
View Lastest Price from 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | TDZD-8
327036-89-5
|
$42.00-77.00 | 99.60% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
327036-89-5
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- TDZD-8
327036-89-5
- $42.00-77.00
- 99.60%
- TargetMol Chemicals Inc.
-
- 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
327036-89-5
- $2.00
- 99%
- Career Henan Chemical Co
