SB216763
- CAS No.
- 280744-09-4
- Chemical Name:
- SB216763
- Synonyms
- CS-332;HY-12012;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);SB 216763, 10 mM in DMSO;SB 216763, GSK3 inhibitor;3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide
- CBNumber:
- CB9493416
- Molecular Formula:
- C19H12Cl2N2O2
- Molecular Weight:
- 371.22
- MDL Number:
- MFCD09753369
- MOL File:
- 280744-09-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| SB 216763 >98% (HPLC) | S3442 | 5mg | $192 |
| SB 216763 >98% (HPLC) | S3442 | 25mg | $728 |
| SB 216763 >98.0%(HPLC) | B5716 | 10mg | $118 |
| SB 216763 >98.0%(HPLC) | B5716 | 50mg | $352 |
| SB 216763 ≥98% | 10010246 | 5mg | $73 |
| More product size | |||
| Melting point | 287-288.6 °C(lit.) |
|---|---|
| Boiling point | 598.1±50.0 °C(Predicted) |
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | Orange solid |
| pka | 7.27±0.60(Predicted) |
| color | orange |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25) |
| InChIKey | JCSGFHVFHSKIJH-UHFFFAOYSA-N |
| SMILES | N1C(=O)C(C2C3=C(N(C)C=2)C=CC=C3)=C(C2=CC=C(Cl)C=C2Cl)C1=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SB216763 price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S3442 | SB 216763 >98% (HPLC) | 280744-09-4 | 5mg | $192 | 2025-07-31 | Buy |
| Sigma-Aldrich | S3442 | SB 216763 >98% (HPLC) | 280744-09-4 | 25mg | $728 | 2025-07-31 | Buy |
| TCI Chemical | B5716 | SB 216763 >98.0%(HPLC) | 280744-09-4 | 10mg | $118 | 2025-07-31 | Buy |
| TCI Chemical | B5716 | SB 216763 >98.0%(HPLC) | 280744-09-4 | 50mg | $352 | 2025-07-31 | Buy |
| Cayman Chemical | 10010246 | SB 216763 ≥98% | 280744-09-4 | 5mg | $73 | 2024-03-01 | Buy |
SB216763 Chemical Properties,Uses,Production
Description
SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.
Uses
SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.
Uses
SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.
Definition
ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
Biochem/physiol Actions
SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
storage
Room temperature
References
[1] M P COGHLAN. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.[J]. Chemistry & biology, 2000, 7 10: 793-803. DOI:10.1016/s1074-5521(00)00025-9
[2] CARMELA GURRIERI. 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 332 3: 785-794. DOI:10.1124/jpet.109.153049
[3] D. CROSS. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.[J]. Journal of Neurochemistry, 2001, 77 1: 94-102. DOI:10.1046/j.1471-4159.2001.t01-1-00251.x
[4] LESLIE A KIRBY. Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells.[J]. PLoS ONE, 2012: e39329. DOI:10.1371/journal.pone.0039329
SB216763 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20292 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hong Kong Tiansheng New Material Trading Co., Ltd | +8617320695765 | zxx@hktiansheng.com | China | 973 | 58 |
View Lastest Price from SB216763 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-22 | SB 216763
280744-09-4
|
US $33.00-72.00 / mg | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-25 | SB216763
280744-09-4
|
US $19.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | SB216763
280744-09-4
|
US $19.00 / KG | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
