ChemicalBook >> CAS DataBase List >>CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

CAS No.: 144750-42-5

Chemical Name:: CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

Synonyms: Tigrose;Clopidogrel EP I;Clopidogrel USP RC A;Clopidogrel ImpurityCl;Clopidogrel EP IMpurity-A;Clopidogrel Impurity A（EP）;Clopidogrel Impurity 10 HCl;Clopidogrel EP Impurity A HCl;Clopidogrel Related CoMpound A;Clopidogrel acid hydrochloride

CBNumber:: CB7505771

Molecular Formula:: C15H14ClNO2S.ClH

Molecular Weight:: 344.26

MDL Number:: MFCD08063656

MOL File:: 144750-42-5.mol

MSDS File:: SDS

Last updated:2026-05-28 05:03:31

Request For Quotation

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Properties

Melting point	147-155°C (dec.)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	powder
color	Off-White to Pale Yellow
optical activity	49.64°(C=0.164g/100mI, MEOH, 20°C, 589nm)
Stability	Hygroscopic
Major Application	pharmaceutical
InChI	1S/C15H14ClNO2S.ClH/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13;/h1-4,6,8,14H,5,7,9H2,(H,18,19);1H/t14-;/m0./s1
InChIKey	FOKSIOUPGDBSLC-UQKRIMTDSA-N
SMILES	Cl.OC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

WGK Germany

WGK 3

HS Code

2934990002

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
2		0

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1990	Clopidogrel Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	144750-42-5	40mg	$939	2026-04-30	Buy
Sigma-Aldrich	1140586	Clopidogrel Related Compound A United States Pharmacopeia (USP) Reference Standard	144750-42-5	20mg	$1560	2026-04-30	Buy
Cayman Chemical	17871	Clopidogrel Carboxylic Acid (hydrochloride) ≥95%	144750-42-5	500μg	$54	2026-04-30	Buy
Cayman Chemical	17871	Clopidogrel Carboxylic Acid (hydrochloride) ≥95%	144750-42-5	1mg	$102	2026-04-30	Buy
Cayman Chemical	17871	Clopidogrel Carboxylic Acid (hydrochloride) ≥95%	144750-42-5	5mg	$418	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR1990	40mg	$939	Buy
1140586	20mg	$1560	Buy
17871	500μg	$54	Buy
17871	1mg	$102	Buy
17871	5mg	$418	Buy

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Chemical Properties, Uses, Production

Uses

Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.

Synthesis

144457-28-3

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

144750-42-5

Example 6: Preparation of (S)-(+)-α-(2-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-acetic acid hydrochloride (Formula (III) hydrochloride) 1. 61 g of (S)-(+)-α-(2-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-acetic acid (the product of Example 5) was dissolved in a solvent mixture of 300 mL of acetone and 15 mL of methanol, and was heated to 40° C. to dissolve completely. 2. 16.4 mL of concentrated hydrochloric acid was slowly added to the above solution, after which the reaction mixture was stirred continuously at room temperature for 2 hours. 3. the reaction mixture was cooled to below 5 °C and kept at this temperature for at least 2 hours to promote crystallization. 4. The precipitated crystals were collected by filtration, washed with 100 mL of cold acetone and subsequently dried under reduced pressure at 40 °C to afford 61 g of the title compound as a white to pale yellow solid (yield: 90%). Product Characterization. - Melting point: 200-201°C - Spin: [α]D20 +64.87° (c=1%, MeOH) - Optical purity: 99.5% ee (HPLC) - 1H-NMR (DMSO-d6, ppm): δ 3.10 (s, 3H), 3.47 (s, 2H), 4.30 (s, 2H), 5.54 (s, 1H), 6.91 (d, 1H, J=4.8Hz), 7.44 (d, 1H, J=4.8Hz), 7.46-7.58 (m, 2H), 7.65 (d, 1H, J=7.4Hz), 7.65 (d, 1H, J=7.4Hz), 7.65 (d, 1H, J=7.4Hz). J=7.4 Hz), 7.97 (d, 1H, J=7.1 Hz) - 13C-NMR (DMSO-d6, ppm): δ 21.78, 48.81, 50.17, 65.43, 125.04, 125.54, 127.99, 128.29, 128.36, 130.37, 130.46, 131.49, 132.02, 134.43, 167.53 - IR (KBr, cm-1): 3435, 3114, 1728

References

[1] Patent: US2008/214821, 2008, A1. Location in patent: Page/Page column 5
[2] Patent: WO2006/137628, 2006, A1. Location in patent: Page/Page column 13

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) synthesis

Synthesis of CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) from Clopidogrel carboxylic acid

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Preparation Products And Raw materials

Raw materials

Clopidogrel Clopidogrel carboxylic acid Methanol Acetone Hydrochloric acid

Water

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Preparation Products

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Suppliers

Global Suppliers ( 142)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Chuangshuo Chemical Technology Co., Ltd	180-62205282 18062205282	turbo_cq@163.com	China	34	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736	2853117764@yongstandards.com	China	9999	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd	18901358086	pharma_reese@126.com	China	48	57
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-83725681-603		China	4484	50
ShenZhen InnoSyn Biotech Co.,Ltd	0755-28351685 18503098468	innosyn@163.com	China	602	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
Wuhan Chuangshuo Chemical Technology Co., Ltd	58
Hubei Xinyang Medical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Adamas Reagent, Ltd.	59
Chemsky（shanghai）International Co.,Ltd.	50
Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd	57
Sinopharm Chemical Reagent Co,Ltd.	79
S.Z. PhyStandard Bio-Tech. Co., Ltd.	50
ShenZhen InnoSyn Biotech Co.,Ltd	55
Bide Pharmatech Ltd.	60

View Latest Price from CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-02	CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) 144750-42-5	$1.00	1KG	99%HPLC	200KG	Career Henan Chemical Co

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
144750-42-5
$1.00
99%HPLC
Career Henan Chemical Co

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Spectrum

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)(144750-42-5)¹HNMR

144750-42-5 (CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)) Related Search:

rac-Clopidogrel Carboxylic Acid Ethyl-S-(+)-Clopidogrel Sulfate Clopidogrel CLOPIDOGREL RELATED COMPOUND B (20 MG) (METHYL(+/-)-(O-CHLOROPHENYL)-4,5-DIHYDROTHIE-NO[2,3-C]PYRIDINE-6(7H)-ACETATE, HYDROCHLORIDE) Clopidogrel Bisulfate

2-Oxo Clopidogrel Hydrochloride(Mixture of diastereomers)

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Clopidogrel Impurity 2/Clopidogrel EP Impurity A HCl/(S)-Clopidogrel Acid Hydrochloride/(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride Clopidogrel EP Impurity A HCl CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Clopidogrel Related Compound A (20 mg) ((S)-(ochlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-aceticv acid, hydrochloride) (S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride Clopidogrel Related CoMpound A Clopidogrel USP Related CoMpound A Clopidogrel acid hydrochloride Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)- Clopidogrel carboxylic acid Impurity alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride Clopidogrel EP IMpurity-A Clopidogrel Carboxylic Acid Hydrochloride (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride Clopidogrel Impurity 1 HCl(Clopidogrel EP Impurity A HCl) (S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride Clopidogrel EP impurity-A (USP RC A) Clopidogrel-related impurities A Clopidogrel USP RC A (+)-(S)-(o-Chlorophenyl)-6,7-dihydrothieno3,2-cpyridine-5(4H)-acetic acid hydrochloride (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride? (Clopidogrel Impurity） Clopidogrel Related Compound A (H0M124) Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-ace (1140586) Clopidogrel Carboxylic Acid Hydrochloride Salt Clopidogrel Impurity A（EP） Clopidogrel Hydrogen Sulfate Impurity A as Hydrochloride Clopidogrel Related Compound A as Hydrochloride Clopidogrel USP Related Compound A as Hydrochloride Clopidogrel EP I (S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, Clopidogrel Impurity 10 HCl Clopidogrel Related Compound A /imp A Clopidogrel Hydrogen Sulfate EP Impurity A as Hydrochloride Clopidogrel ImpurityCl (2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogre Clopidogrel EP Impurity A Hydrochloride (2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogrel Acid Hydrochloride) Clopidogrel Impurity 10 HCl ((S)-Clopidogrel Carboxylic Acid) Tigrose 144750-42-5 1444750-42-5 34426 C15H14ClNO2SClH