Glutaminase-IN-1
- CAS No.
- 2247127-79-1
- Chemical Name:
- Glutaminase-IN-1
- Synonyms
- Glutamise-IN-1;CB839 derivative;Glutaminase-IN-1;Glutaminase inhibitor 1;Glutaminase-IN-1, 10 mM in DMSO;GlutaminaseIN1,Glutaminase IN 1;2-Pyridineacetamide, N-[5-[4-[6-[[2-[3-(trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-selenadiazol-2-yl]-
- CBNumber:
- CB75419743
- Molecular Formula:
- C26H24F3N7O3Se
- Molecular Weight:
- 618.47
- MDL Number:
- MFCD31807665
- MOL File:
- 2247127-79-1.mol
- MSDS File:
- SDS
Glutaminase-IN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42339 | Glutaminase-IN-1 ≥95% | 2247127-79-1 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 42339 | Glutaminase-IN-1 ≥95% | 2247127-79-1 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 42339 | Glutaminase-IN-1 ≥95% | 2247127-79-1 | 10mg | $176 | 2026-04-30 | Buy |
| ChemScene | CS-0083090 | Glutaminase-IN-1 98.09% | 2247127-79-1 | 5mg | $130 | 2026-06-04 | Buy |
| ChemScene | CS-0083090 | Glutaminase-IN-1 98.09% | 2247127-79-1 | 10mg | $184 | 2026-06-04 | Buy |
Glutaminase-IN-1 Chemical Properties,Uses,Production
Uses
Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
in vivo
Glutaminase-IN-1(10 mg/kg, s.c.) reduced the size and weight of the HCT116 tumor, and statistical analysis showed that the 40% reduction in tumor weight by CPD20 is statistically significant. Glutaminase-IN-1 could statistically significantly prolong the survival of H22-bearing mice[1].
References
[1] Chen Z, et al. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2018 Dec 13. DOI:10.1021/acs.jmedchem.8b01198
Glutaminase-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Glutaminase-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 50706066 15221275939 | shenlinxing@macklin.cn | China | 14849 | 58 |
