FGTI-2734
- CAS No.
- 1247018-19-4
- Chemical Name:
- FGTI-2734
- Synonyms
- FGTI-2734;FGTI-2734, 10 mM in DMSO;N-(2-((4-Cyano-2-fluorophenyl)((1-methyl-1H-imidazol-5-yl)methyl)amino)ethyl)-N-(cyclohexylmethyl)pyridine-2-sulfonamide;2-Pyridinesulfonamide, N-[2-[(4-cyano-2-fluorophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl]-N-(cyclohexylmethyl)-;pancreatic,patient-derived,geranylgeranyl,farnesyl,inhibit,Farnesyl Transferase,mimetic,FGTI2734,Inhibitor,membrane,Ftase,FGTI-2734,KRAS,FGTI 2734,C-terminal,transferase,tumors,localization
- CBNumber:
- CB75540586
- Molecular Formula:
- C26H31FN6O2S
- Molecular Weight:
- 510.63
- MDL Number:
- MFCD32174296
- MOL File:
- 1247018-19-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
FGTI-2734 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37694 | FGTI-2734 ≥95% | 1247018-19-4 | 1mg | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 37694 | FGTI-2734 ≥95% | 1247018-19-4 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 37694 | FGTI-2734 ≥95% | 1247018-19-4 | 10mg | $225 | 2026-04-30 | Buy |
| Cayman Chemical | 37694 | FGTI-2734 ≥95% | 1247018-19-4 | 25mg | $492 | 2026-04-30 | Buy |
| Biosynth | XZB01819 | FGTI-2734 | 1247018-19-4 | 10mg | $941.3 | 2026-06-05 | Buy |
FGTI-2734 Chemical Properties, Uses, Production
Description
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor. It can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors.
Uses
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors[1].
in vivo
FGTI-2734 (intraperitoneally; 100 mg/kg/daily for 18 to 25 days) only inhibits tumor growth in mutant KRAS-dependent tumors but not in mutant KRAS-independent tumors[1].
| Animal Model: | Male SCID-bg mice following injection of MiaPaCa2, L3.6pl, Calu6, A549, H460 and DLD1 cancer cells[1] |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneally; daily; for 18 to 25 days |
| Result: | Inhibited tumor growth in mutant KRAS-dependent tumors. |
target
FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively.
References
[1] Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21. DOI:10.1158/1078-0432.CCR-18-3399
FGTI-2734 Preparation Products And Raw materials
Raw materials
Preparation Products
FGTI-2734 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1162 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Aikon International Limited | 17714375163 | hywu@aikonchem.com | China | 9974 | 58 |
