Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>MAP4K4-IN-17

MAP4K4-IN-17

MAP4K4-IN-17 Structure
MAP4K4-IN-17 structure
CAS No.
1811510-58-3
Chemical Name:
MAP4K4-IN-17
Synonyms
Compound 17;MAP4K4-IN-3;MAP4K4-IN-17;MAP4K4-IN-3, 10 mM in DMSO;5-(6-Amino-5-(4-chlorophenyl)pyridin-3-yl)pyrimidin-2-amine;2-Pyrimidinamine, 5-[6-amino-5-(4-chlorophenyl)-3-pyridinyl]-;MAP4K,MAPK Kinase Kinase Kinase,Inhibitor,MAP4K4 IN 3,MAP4K4IN3,inhibit,MAP-4K4-IN-3
CBNumber:
CB75867412
Molecular Formula:
C15H12ClN5
Molecular Weight:
297.74
MDL Number:
MFCD34469362
MOL File:
1811510-58-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

MAP4K4-IN-17 Properties

Boiling point 548.1±60.0 °C(Predicted)
Density 1.377±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 10 mg/mL (33.59 mM; ultrasonic and warming and heat to 60°C)
pka 4.31±0.50(Predicted)
form Solid
color Off-white to light yellow

MAP4K4-IN-17 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0088400 MAP4K4-IN-3 99.77% 1811510-58-3 5mg $54 2026-06-04 Buy
ChemScene CS-0088400 MAP4K4-IN-3 99.77% 1811510-58-3 10mg $97 2026-06-04 Buy
ChemScene CS-0088400 MAP4K4-IN-3 99.77% 1811510-58-3 25mg $206 2026-06-04 Buy
ChemScene CS-0088400 MAP4K4-IN-3 99.77% 1811510-58-3 50mg $325 2026-06-04 Buy
ChemScene CS-0088400 MAP4K4-IN-3 99.77% 1811510-58-3 100mg $520 2026-06-04 Buy
Product number Packaging Price Buy
CS-0088400 5mg $54 Buy
CS-0088400 10mg $97 Buy
CS-0088400 25mg $206 Buy
CS-0088400 50mg $325 Buy
CS-0088400 100mg $520 Buy

MAP4K4-IN-17 Chemical Properties,Uses,Production

Uses

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

in vivo

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].

IC 50

MAP4K4: 14.9 nM (IC50)

References

[1] Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. DOI:10.1021/acsmedchemlett.5b00215
[2] Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125. DOI:10.1021/acs.jmedchem.8b00152

MAP4K4-IN-17 Preparation Products And Raw materials

Raw materials

Preparation Products

MAP4K4-IN-17 Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 10000 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 4960 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Supplier Advantage
BOC Sciences 65
Dalian Meilun Biotech Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
Zhejiang Huida Biotech Co., LTD 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Bide Pharmatech Ltd. 58

View Lastest Price from MAP4K4-IN-17 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MAP4K4-IN-3 pictures 2026-07-27 MAP4K4-IN-3
1811510-58-3
 $39.00-155.00 99.50% 10g TargetMol Chemicals Inc.
MAP4K4-IN-3 pictures 2026-07-27 MAP4K4-IN-3
1811510-58-3
 $39.00-155.00 99.50% 10g TargetMol Chemicals Inc.
  • MAP4K4-IN-3 pictures
  • MAP4K4-IN-3
    1811510-58-3
  • $39.00-155.00
  • 99.50%
  • TargetMol Chemicals Inc.
  • MAP4K4-IN-3 pictures
  • MAP4K4-IN-3
    1811510-58-3
  • $39.00-155.00
  • 99.50%
  • TargetMol Chemicals Inc.

MAP4K4-IN-17 Spectrum

MAP4K4-IN-17(1811510-58-3)1HNMR

1811510-58-3(MAP4K4-IN-17)Related Search:

5-(4-CHLOROPHENYL)PYRIMIDIN-4-AMINE 2-Pyridinamine, 5-(4-chlorophenyl)- 5-(2-chlorophenyl)pyrimidine-2,4-diamine 4-Pyrimidinamine,5-(2-chlorophenyl)- PF-6260933
5-(4-chlorophenyl)pyrimidine-2,4-diamine

1of2

MAP4K4-IN-17 MAP4K4-IN-3 2-Pyrimidinamine, 5-[6-amino-5-(4-chlorophenyl)-3-pyridinyl]- Compound 17 MAP4K,MAPK Kinase Kinase Kinase,Inhibitor,MAP4K4 IN 3,MAP4K4IN3,inhibit,MAP-4K4-IN-3 5-(6-Amino-5-(4-chlorophenyl)pyridin-3-yl)pyrimidin-2-amine MAP4K4-IN-3, 10 mM in DMSO 1811510-58-3