PF-6260933
- CAS No.
- 1811510-56-1
- Chemical Name:
- PF-6260933
- Synonyms
- PF06260933;PF-6260933;PF-06260933 (PF 6260933;PF-06260933, 10 mM in DMSO;5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
- CBNumber:
- CB53344890
- Molecular Formula:
- C16H13ClN4
- Molecular Weight:
- 296.75
- MDL Number:
- MFCD30532622
- MOL File:
- 1811510-56-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
PF-6260933 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29220 | PF-6260933 ≥98% | 1811510-56-1 | 10mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 29220 | PF-6260933 ≥98% | 1811510-56-1 | 50mg | $460 | 2026-04-30 | Buy |
| Cayman Chemical | 29220 | PF-6260933 ≥98% | 1811510-56-1 | 100mg | $674 | 2026-04-30 | Buy |
| ChemScene | CS-8001 | PF-06260933 99.39% | 1811510-56-1 | 5mg | $156 | 2026-06-04 | Buy |
| ChemScene | CS-8001 | PF-06260933 99.39% | 1811510-56-1 | 10mg | $247 | 2026-06-04 | Buy |
PF-6260933 Chemical Properties,Uses,Production
Uses
PF-06260933 is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
Biological Activity
PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.
in vitro
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
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in vivo
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.
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target
| Target | Value |
| MAP4K4 () | 3.7 nM |
IC 50
MAP4K4: 3.7 nM (IC50)
References
[1] Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. DOI:10.1021/acsmedchemlett.5b00215
[2] Roth Flach RJ, et al. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun. 2015 Dec 21;6:8995. DOI:10.1038/ncomms9995
PF-6260933 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2971 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 |
View Lastest Price from PF-6260933 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | PF-06260933
1811510-56-1
|
$42.00-166.00 | 99.63% | 10g | TargetMol Chemicals Inc. |
-
- PF-06260933
1811510-56-1
- $42.00-166.00
- 99.63%
- TargetMol Chemicals Inc.
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