5-Nitro-1H-pyrrolo[2,3-b]pyridine
![5-Nitro-1H-pyrrolo[2,3-b]pyridine Structure](CAS/GIF/101083-92-5.gif)
- CAS No.
- 101083-92-5
- Chemical Name:
- 5-Nitro-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 5-NITRO-7-AZAINDOLE;5-Nitro-7-azaindole,97%;5-Nitro-7-aza-1H-indole;5-Nitro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-nitro-;5-nitro-1H-pyrrolo[2,3-b]pyridine 97%min;TIANFU-CHEM 101083-92-5 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
- CBNumber:
- CB7690297
- Molecular Formula:
- C7H5N3O2
- Molecular Weight:
- 163.13
- MDL Number:
- MFCD06659682
- MOL File:
- 101083-92-5.mol
- MSDS File:
- SDS
| Melting point | 280℃ |
|---|---|
| Boiling point | 392.8±35.0 °C(Predicted) |
| Density | 1.58±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 0.65±0.20(Predicted) |
| color | yellow |
| InChI | InChI=1S/C7H5N3O2/c11-10(12)6-3-5-1-2-8-7(5)9-4-6/h1-4H,(H,8,9) |
| InChIKey | INMIPMLIYKQQID-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC([N+]([O-])=O)=CN=2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
5-Nitro-1H-pyrrolo[2,3-b]pyridine price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 285044 | 5-Nitro-7-azaindole Asreported | 101083-92-5 | 250mg | $319 | 2026-06-03 | Buy |
| Usbiological | 285044 | 5-Nitro-7-azaindole Asreported | 101083-92-5 | 500mg | $432 | 2026-06-03 | Buy |
| Usbiological | 285044 | 5-Nitro-7-azaindole Asreported | 101083-92-5 | 1g | $559 | 2026-06-03 | Buy |
| Usbiological | 285044 | 5-Nitro-7-azaindole Asreported | 101083-92-5 | 2g | $744 | 2026-06-03 | Buy |
| Usbiological | 285044 | 5-Nitro-7-azaindole Asreported | 101083-92-5 | 5g | $955 | 2026-06-03 | Buy |
5-Nitro-1H-pyrrolo[2,3-b]pyridine Chemical Properties, Uses, Production
Uses
5-Nitro-1H-pyrrolo[2,3-b]pyridine is a reagent used in the synthesis of Cdc7 kinase inhibitors used as a novel cancer therapy. Also an intermediate in the synthesis of 4-anilinoquinazolines as potential anticancer agents.
Synthesis
![1H-Pyrrolo[2,3-b]pyridine, 5-nitro-1-(phenylsulfonyl)-](/CAS/GIF/937012-11-8.gif)
937012-11-8
![5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE](/CAS/GIF/101083-92-5.gif)
101083-92-5
To a stirred suspension of 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (10.2 g, 33 mmol) in methanol (250 mL) was added powdered sodium hydroxide (2 g, 50 mmol) in batches. After stirring the reaction mixture for 30 min at room temperature, powdered sodium hydroxide (2 g, 50 mmol) and dichloromethane (50 mL) were added again and stirring was continued for 30 min. Upon completion of the reaction, the mixture was concentrated, followed by the addition of a mixed solution of 2N HCl (50 mL) and water (200 mL), and the resulting mixture was filtered. The yellow filter cake was washed with water and dried to afford 5-nitro-1H-pyrrolo[2,3-b]pyridine (4.6 g, 28.2 mmol, 85% yield). The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 6.78 (dd, J = 3.50, 1.83 Hz, 1H), 7.79 (dd, J = 3.35, 2.59 Hz, 1H), 8.90-8.92 (m, 1H), 9.13 (d, J = 2.59 Hz, 1H), 12.05- 12.92 (m, 1H).
References
[1] Patent: US2007/112020, 2007, A1. Location in patent: Page/Page column 36
5-Nitro-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 5-Nitro-1H-pyrrolo[2,3-b]pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE pictures](https://img.chemicalbook.com/ProductImageEN/2019-8/Small/749ae852-fb61-4b5b-ba66-8a625c577daa.png) |
2019-08-06 | 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
101083-92-5
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 5-NITRO-1H-PYRROLO[2,3-B]PYRIDINE
101083-92-5
- $8.80
- 97%-99%
- Career Henan Chemical Co
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