FORTUNELLIN
- CAS No.
- 20633-93-6
- Chemical Name:
- FORTUNELLIN
- Synonyms
- ACACETIN-7-O-NEOHESPERIDOSIDE;FORTUNELLIN;ACACETIN-7-NEOHESPERIDOSIDE;4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-
- CBNumber:
- CB7713662
- Molecular Formula:
- C28H32O14
- Molecular Weight:
- 592.55
- MDL Number:
- MFCD00063944
- MOL File:
- 20633-93-6.mol
- MSDS File:
- SDS
FORTUNELLIN price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 380306 | Fortunellin ≥98% | 20633-93-6 | 10mg | $585 | 2026-06-03 | Buy |
| Biosynth | OA71574 | Acacetin-7-neohesperidoside | 20633-93-6 | 1mg | $544.22 | 2026-06-04 | Buy |
| Biosynth | OA71574 | Acacetin-7-neohesperidoside | 20633-93-6 | 2mg | $816.34 | 2026-06-04 | Buy |
| Biosynth | OA71574 | Acacetin-7-neohesperidoside | 20633-93-6 | 5mg | $1451.2 | 2026-06-04 | Buy |
| Biosynth | OA71574 | Acacetin-7-neohesperidoside | 20633-93-6 | 10mg | $2176.9 | 2026-06-04 | Buy |
FORTUNELLIN Chemical Properties, Uses, Production
Description
Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.
Chemical Properties
Off-white to light yellow Solid
Uses
Fortunellin is a flavonoid that can be isolated from kumquat (Fortunella margarita) fruit. Studies have shown that Fortunellin inhibits LPS-induced inflammation and ROS production in H9C2 cells, and also prevents fructose-induced inflammation and oxidative stress by enhancing the AMPK/Nrf2 pathway. In addition, Fortunellin has a dual role in the prevention and treatment of coronaviral disease, with antiviral activity against SARS-CoV-2 and anti-inflammatory immunomodulatory capacity in the host.
Biological Functions
Fortunellin (acacetin 7-O-neohesperidoside) is a citrus flavonoid isolated from kumquat fruit. Kumquat extract has attracted much attention recently for its beneficial effects on human health, which include antitumor, antioxidant and anti-inflammatory characteristics . The beneficial effects of flavonoids on IBD have been confirmed in many studies. However, although fortunellin is the main flavonoid in kumquat, there is a lack of information on its alleviation of IBD.
Mechanism of action
Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent in inflammatory diseases. Fortunellin ameliorated colitis symptoms, including excessive inflammation and oxidative stress. Fortunellin decreased epithelial cell apoptosis through inhibiting PTEN expression in colitis. Fortunellin-induced downregulation of PTEN could be counteracted by miR-374a depletion. Moreover, knockdown of miR-374a in vivo partly inhibited the effects of fortunellin on rat colitis.
FORTUNELLIN Preparation Products And Raw materials
FORTUNELLIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| Beijing LAL Pharmaceutical Co., Ltd. | 010-010-62452898 13581984929 | jlzhang929@163.com | China | 91 | 58 |
