Ethyl 3,4-dihydroxycinnamate
- CAS No.
- 66648-50-8
- Chemical Name:
- Ethyl 3,4-dihydroxycinnamate
- Synonyms
- Ethyl trans-caffeate;(E)-Ethyl Dihydroxycinnamate;Zinc01614326;ethyl (E)-caffeate;Ethyl trans-caffeate-RM;E-Caffeic acid ethyl ester;Ethyl-3,4-dihydroxycinnamte;Ethyl 3,4-dihydroxycinnamate;Ethyl trans-caffeate (Standard);Ethyl 3,4-dihydroxycinnamate,97%
- CBNumber:
- CB7713697
- Molecular Formula:
- C11H12O4
- Molecular Weight:
- 208.21
- MDL Number:
- MFCD00045754
- MOL File:
- 66648-50-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 147~151℃ |
|---|---|
| Boiling point | 148-149 °C |
| Density | 1.271±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 8.71±0.18(Predicted) |
| form | Off-white to brown solid. |
| color | White to off-white |
| biological source | plant |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChI | 1S/C11H12O4/c1-2-15-11(14)6-4-8-3-5-9(12)10(13)7-8/h3-7,12-13H,2H2,1H3/b6-4+ |
| InChIKey | WDKYDMULARNCIS-GQCTYLIASA-N |
| SMILES | O(CC)C(=O)\C=C\c1cc(c(cc1)O)O |
| LogP | 2.418 (est) |
| FDA UNII | 76GBB1JU5Y |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Ethyl 3,4-dihydroxycinnamate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB01081 | Ethyl 3,4-Dihydroxycinnamate ≥90% (LC/MS-ELSD) | 66648-50-8 | 1MG | $407 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL83086 | Ethyl trans-caffeate phyproof? Reference Substance | 66648-50-8 | 100mg | $357 | 2026-04-30 | Buy |
| Sigma-Aldrich | CDS000693 | Ethyl 3,4-dihydroxycinnamate AldrichCPR | 66648-50-8 | 100mg | $77.9 | 2026-04-30 | Buy |
| Usbiological | 275457 | Ethyl dihydroxycinnamate Asreported | 66648-50-8 | 1g | $382 | 2026-06-03 | Buy |
| Usbiological | 275457 | Ethyl dihydroxycinnamate Asreported | 66648-50-8 | 2g | $556 | 2026-06-03 | Buy |
Ethyl 3,4-dihydroxycinnamate Chemical Properties, Uses, Production
Uses
Ethyl 3,4-dihydroxycinnamate shows anti-inflammatory, immunomodulatory, and anti-carcinogenic properties. It is a potent and specific inhibitor of NF-κB and its downstream inflammatory mediators: NOS2 (inducible nitric oxide synthase; NOS; NOS II), Cox-2 (cyclooxygenase-2), and prostaglandin E2 (PGE2). Ethyl 3,4-Dihydroxycinnamate prevents DNA single-strand breaks caused by H2O2.
Definition
ChEBI: Ethyl trans-caffeate is an ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol. It has a role as an anti-inflammatory agent and an antineoplastic agent. It is an alkyl caffeate ester and an ethyl ester. It is functionally related to a trans-caffeic acid.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Ethyl dihydroxycinnamate exhibits potent cytotoxicity, inhibits COX-2 and P-hydroxybenzoic acid, both involved in inflammation and cytokine synthesis. It demonstrates antibacterial efficacy against MRSA and Bacillus subtilis and inhibits cancer cell growth, countering tumor formation.
Ethyl 3,4-dihydroxycinnamate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 3,4-dihydroxycinnamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89664 | 60 |
View Latest Price from Ethyl 3,4-dihydroxycinnamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Ethyl trans-caffeate
66648-50-8
|
$78.00 | 99.84% | 10g | TargetMol Chemicals Inc. |
-
- Ethyl trans-caffeate
66648-50-8
- $78.00
- 99.84%
- TargetMol Chemicals Inc.
