4,6-Dimethyl-2-nitroaniline
- CAS No.
- 1635-84-3
- Chemical Name:
- 4,6-Dimethyl-2-nitroaniline
- Synonyms
- 6-nitro-2,4-xylidine;4,6-Dimethyl-2-nitroaniline;2,4-Dimethyl-6-nitroBenzenamine;2,4-Dimethyl-6-nitroaniline 97%;2,4-Dimethyl-6-nitroaniline, 97%;4,6-Dimethyl-2-nitroaniline, 97%,;Benzenamine, 2,4-dimethyl-6-nitro-;5-NITRO-4-AMINO-1,3-DIMETHYLBENZENE;1-(2-methylpropyl)pyrrolidine-2,5-dione;4,6-DIMETHYL-2-NITROANILINE, TECH., 90%
- CBNumber:
- CB7718526
- Molecular Formula:
- C8H10N2O2
- Molecular Weight:
- 166.18
- MDL Number:
- MFCD00007739
- MOL File:
- 1635-84-3.mol
- MSDS File:
- SDS
| Melting point | 64-68 °C(lit.) |
|---|---|
| Boiling point | 319.1±37.0 °C(Predicted) |
| Density | 1.220±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| pka | 0.27±0.25(Predicted) |
| Appearance | Yellow to orange Solid |
| FDA UNII | ZF8VRN3SKA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335-H302-H312-H332-H331 | |||||||||
| Precautionary statements | P304+P340-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214990 | |||||||||
| NFPA 704 |
|
4,6-Dimethyl-2-nitroaniline price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR14484 | 2,4-Dimethyl-6-nitroaniline >98% | 1635-84-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR14484 | 2,4-Dimethyl-6-nitroaniline >98% | 1635-84-3 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR14484 | 2,4-Dimethyl-6-nitroaniline >98% | 1635-84-3 | 25g | $41 | 2026-06-04 | Buy |
| Apolloscientific | OR14484 | 2,4-Dimethyl-6-nitroaniline >98% | 1635-84-3 | 100g | $160 | 2026-06-04 | Buy |
| Activate Scientific | AS21731 | 4,6-Dimethyl-2-nitroaniline 97% | 1635-84-3 | 5g | $20 | 2026-06-04 | Buy |
4,6-Dimethyl-2-nitroaniline Chemical Properties,Uses,Production
Uses
2,4-Dimethyl-6-nitroaniline is used as a reagent in the synthetic preparation of 1,2-bis-substituted benzimidazoles as nonnucleoside HIV-1 reverse transcriptase inhibitors.
Synthesis
95-68-1
1635-84-3
General procedure for the synthesis of 2-nitro-4,6-dimethylaniline from 2,4-dimethylaniline: 2,4-dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL) and concentrated nitric acid (5 mL) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and then diluted with ice water (200 mL). Subsequently, concentrated hydrochloric acid (10 mL) was added dropwise to the mixture and the resulting mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was diluted with aqueous ammonium hydroxide and the resulting orange solid was filtered and dried to give 2-nitro-4,6-dimethylaniline (10.6 g, 97% yield).
References
[1] Patent: WO2009/25478, 2009, A1. Location in patent: Page/Page column 33; 52-53
[2] Patent: US2010/197673, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: KR101511771, 2015, B1. Location in patent: Paragraph 0406; 0407
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 10, p. 1267 - 1273
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8743 - 8749
4,6-Dimethyl-2-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Lastest Price from 4,6-Dimethyl-2-nitroaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-12 | 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-DIMETHYL-2-NITROANILINE
1635-84-3
- $1.00
- 99%
- Career Henan Chemical Co
1635-84-3(4,6-Dimethyl-2-nitroaniline)Related Search:
1of4
