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Z-D-Met-OH

Z-D-Met-OH Structure
Z-D-Met-OH structure
CAS No.
28862-80-8
Chemical Name:
Z-D-Met-OH
Synonyms
N-CARBOBENZOXY-D-METHIONINE;Z-D-MET;Cbz-D-Met;Z-D-Met-OH;CBZ-D-MET-OH;N-Cbz-D-Met-OH;Z-D-METHIONINE;Cbz-D-Methinine;CBZ-D-METHIONINE;N-CBZ-D-METHIONINE
CBNumber:
CB7757394
Molecular Formula:
C13H17NO4S
Molecular Weight:
283.34
MDL Number:
MFCD00026043
MOL File:
28862-80-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:06
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Z-D-Met-OH Properties

Melting point 67-69°C
Density 1.253
refractive index 26 ° (C=1, MeOH)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Safety Statements  24/25
HS Code  29225090
NFPA 704
1
0 0

Z-D-Met-OH price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S777129 CARBOBENZYLOXY-D-METHIONINE AldrichCPR 28862-80-8 50MG $32.7 2026-04-30 Buy
TCI Chemical C0665 N-Carbobenzoxy-D-methionine >98.0%(T) 28862-80-8 5g $31 2026-04-30 Buy
TCI Chemical C0665 N-Carbobenzoxy-D-methionine >98.0%(T) 28862-80-8 25g $94 2026-04-30 Buy
Usbiological 458477 N-Cbz-D-methionine 28862-80-8 5g $403 2026-06-03 Buy
Usbiological 458477 N-Cbz-D-methionine 28862-80-8 25g $785 2026-06-03 Buy
Product number Packaging Price Buy
S777129 50MG $32.7 Buy
C0665 5g $31 Buy
C0665 25g $94 Buy
458477 5g $403 Buy
458477 25g $785 Buy

Z-D-Met-OH Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).

Synthesis

D-Methionine

348-67-4

Benzyl chloroformate

501-53-1

N-Cbz-L-methionine

1152-62-1

General procedure for the synthesis of Z-L-methionine from D-methionine and benzyl chloroformate: (2R)-2-Amino-4-(methylthioalkyl)butyric acid (4.90 g, 32.84 mmol) and sodium carbonate (16.91 g, 159.54 mmol) were dissolved in water (100 mL) at room temperature. Subsequently, a solution of benzyl chloroformate (5.59 g, 32.74 mmol) in dioxane (50 mL) was added slowly and dropwise over 10 minutes. The resulting reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (100 mL). The reaction mixture was extracted with ethyl acetate (300 mL x 3) and the organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by chromatography on a C18 reversed-phase column using gradient elution with aqueous acetonitrile (0 to 50% acetonitrile, 30 min) to afford (2R)-2-[[(benzyloxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid as a yellow oil (3.48 g, 36% yield).

References

[1] Journal of Agricultural and Food Chemistry, 1995, vol. 43, # 10, p. 2728 - 2734
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 937 - 960
[3] Patent: WO2017/106607, 2017, A1. Location in patent: Paragraph 00400

Z-D-Met-OH Preparation Products And Raw materials

Raw materials

D-Methionine Benzyl chloroformate Sodium carbonate Water 1,4-Dioxane

Preparation Products

Z-D-Met-OH Suppliers

Global Suppliers ( 154)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60

View Latest Price from Z-D-Met-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cbz-D-Met-OH pictures 2026-09-15 Cbz-D-Met-OH
28862-80-8
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Z-D-MET-OH pictures 2019-07-06 Z-D-MET-OH
28862-80-8
 $1.00 1KG 99% 20kg Career Henan Chemical Co
  • Z-D-MET-OH pictures
  • Z-D-MET-OH
    28862-80-8
  • $1.00
  • 99%
  • Career Henan Chemical Co

Z-D-Met-OH Spectrum

Z-D-MET-OH(28862-80-8)1HNMRZ-D-MET-OH(28862-80-8)IR1

28862-80-8 (Z-D-Met-OH) Related Search:

Z-D-Thr(tBu)-OH dcha Z-D-Glu-OH Z-D-Tyr-OH Z-D-Phg-OH Z-D-Met-Onp
Z-D-Tyr(tBu)-OMe Z-D-Nle-OH Z-D-Thr-OH Z-D-Arg-OH Z-D-MeAla-OH
Z-D-His-OH Z-D-Lys-OH Z-D-Gln-OH Z-D-Nva-OH Z-D-Nle-ONp
Z-L-MET-OH,Z-MET-OH,N-Benzyloxycarbonyl-L-methionine~Z-Met-OH N-Bsmoc-L-methionine Boc-Met-OH dcha

1of4

N-CBZ-D-METHIONINE N-ALPHA-CBZ-D-METHIONINE N-ALPHA-CARBOBENZOXY-D-METHIONINE N-ALPHA-BENZYLOXYCARBONYL-D-METHIONINE Z-D-METHIONINE Z-D-METHIONINE extrapure (R)-2-(Benzyloxycarbonylamino)-4-methylthiobutyric acid N-Cbz-D-Met-OH CBZ-D-MET-OH CBZ-D-METHIONINE Z-D-MET Cbz-D-Methinine (R)-2-(benzyloxycarbonylamino)-4-(methylthio)butanoic acid D-(Carbobenzyloxy)methionine N-Carbobenzyloxy-D-methionine (2R)-2-{[(benzyloxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid N-Cbz-D-methionine Z-D-Met-OH Z-D-methionine≥ 99% (HPLC) N-Carbobenzoxy-D-methionine > D-Methionine, N-[(phenylmethoxy)carbonyl]- Z-D-MET-OH USP/EP/BP (2R)-4-methylsulfanyl-2-(phenylmethoxycarbonylamino)butanoic acid N-Cbz-D-methionine, 98% [Z-D-MetOH] CARBOBENZYLOXY-D-METHIONINE N-α-Benzyloxycarbonyl-D-methionine N-CARBOBENZOXY-D-METHIONINE Cbz-D-Met Z-D-Met-OH 28862-80-8 CARBOXYLIC ACID Amino Acids (N-Protected) Cbz-Amino Acids Protected & Labeled Amino Acids Amino Acids Amino Acids (N-Protected) Biochemistry Cbz-Amino Acids