1-N-Cbz-4-cyanopiperidine
- CAS No.
- 161609-84-3
- Chemical Name:
- 1-N-Cbz-4-cyanopiperidine
- Synonyms
- BUTTPARK 93\50-50;1-Z-4-cyanopiperidine;1-CBZ-4-CYANOPIPERIDINE;N-CBZ-4-cyanopiperidine;1-N-CBZ-4-CYANO-PIPERIDINE;1-N-Cbz-4-cycano-piperidine;1-N-CBZ-PIPERIDINE-4-CARBONITRILE;4-Cyanopiperidine, N-CBZ protected;BENZYL-4-CYANOPIPERIDINE-1-CARBOXYLATE;4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
- CBNumber:
- CB7763001
- Molecular Formula:
- C14H16N2O2
- Molecular Weight:
- 244.29
- MDL Number:
- MFCD04115340
- MOL File:
- 161609-84-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280 |
| HS Code | 29333990 |
1-N-Cbz-4-cyanopiperidine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 68146 | 1-N-CBZ-4-CYANO-PIPERIDINE 97% | 161609-84-3 | 5G | $19 | 2026-04-30 | Buy |
| AstaTech | 68146 | 1-N-CBZ-4-CYANO-PIPERIDINE 97% | 161609-84-3 | 25G | $69 | 2026-04-30 | Buy |
| AstaTech | 68146 | 1-N-CBZ-4-CYANO-PIPERIDINE 97% | 161609-84-3 | 100G | $289 | 2026-04-30 | Buy |
| Apolloscientific | OR41009 | 4-Cyanopiperidine, N-CBZ protected 95% | 161609-84-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR41009 | 4-Cyanopiperidine, N-CBZ protected 95% | 161609-84-3 | 5g | $26 | 2026-06-04 | Buy |
1-N-Cbz-4-cyanopiperidine Chemical Properties, Uses, Production
Synthesis
167757-45-1
161609-84-3
General procedure for the synthesis of 1-N-Cbz-4-cyanopiperidine from 1-Cbz-piperidine-4-carboxamide: 1-Cbz-piperidine-4-carboxamide (1.0 mmol) and triethylamine (Et3N, 1.5 mmol) were dissolved in ethyl acetate (EtOAc, 1 mL, 1 M) at room temperature. Subsequently, XtalFluor-E (1.1 mmol) was added in batches. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution. Next, the reaction mixture was washed with aqueous sodium carbonate (Na2CO3) solution and extracted with dichloromethane (CH2Cl2, 2 × 10 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the crude product. If necessary, the crude product can be purified by fast column chromatography.
References
[1] Synthesis (Germany), 2015, vol. 47, # 23, p. 3758 - 3766
1-N-Cbz-4-cyanopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Cbz-4-cyanopiperidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
