Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
- CAS No.
- 167757-45-1
- Chemical Name:
- Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
- Synonyms
- BUTTPARK 75\50-02;N-Z-ISONIPECOTINAMIDE;Benzyl Benzoate Impurity 15;1-Cbz-4-piperidinecarboxamide;1-N-CBZ-PIPERIDINE-4-CARBOXAMIDE;Benzyl 4-carbamoyl-1-piperidinecarboxylate;Benzyl 4-(aminocarbonyl)-1-pyridinecarboxylate;Benzyl 4-(aminocarbonyl)piperidine-1-carboxylate;4-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;4-carbamoyl-2-piperidinecarboxylic acid (phenylmethyl) ester
- CBNumber:
- CB4750950
- Molecular Formula:
- C14H18N2O3
- Molecular Weight:
- 262.3
- MDL Number:
- MFCD01568760
- MOL File:
- 167757-45-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 130 °C |
|---|---|
| Boiling point | 475.5±44.0 °C(Predicted) |
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 16.40±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C14H18N2O3/c15-13(17)12-6-8-16(9-7-12)14(18)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,17) |
| InChIKey | UNJWOPBEKPMSGH-UHFFFAOYSA-N |
| SMILES | N1(C(OCC2=CC=CC=C2)=O)CCC(C(N)=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 266691 | Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)pyridinecarboxylate Asreported | 167757-45-1 | 1g | $376 | 2026-06-03 | Buy |
| Usbiological | 266691 | Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)pyridinecarboxylate Asreported | 167757-45-1 | 2g | $562 | 2026-06-03 | Buy |
| Usbiological | 266691 | Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)pyridinecarboxylate Asreported | 167757-45-1 | 5g | $779 | 2026-06-03 | Buy |
| Usbiological | 266691 | Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)pyridinecarboxylate Asreported | 167757-45-1 | 10g | $1084 | 2026-06-03 | Buy |
| Chem-Impex | 17207 | N-Z-Isonipecotinamide ≥96%(HPLC) | 167757-45-1 | 1G | $74.81 | 2026-05-19 | Buy |
Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate Chemical Properties, Uses, Production
Synthesis
39546-32-2
1885-14-9
167757-45-1
Piperidine-4-carboxamide (5 g, 39 mmol) and benzyl chloroformate (5.54 mL, 39 mmol) were added dropwise to 1N NaOH solution (39 mL, 39 mmol) in a solvent mixture of water (30 mL) and acetone (40 mL), and the pH was maintained between 6 and 8 during the reaction. The reaction mixture was stirred at room temperature for 3 hours. Subsequently, the acetone was removed by evaporation, the resulting precipitate was collected by filtration and dried under reduced pressure at 70 °C to afford benzyl-4-carbamoylpiperidine-1-carboxylate 7.75 g in 76% yield. The product was analyzed by HPLC with a retention time (Rt) of 4.54 min. 1H NMR (600 MHz, DMSO-d6) δ ppm: 7.41-7.29 (m, 5H), 7.25 (br.s, 1H), 6.76 (br.s, 1H), 5.07 (s, 2H), 4.06-3.81 (m, J=13.2 Hz, 2H ), 2.92-2.72 (m, 2H), 2.27 (tt, J=3.7,11.5Hz, 1H), 1.75-1.64 (m, 2H), 1.40 (dq, J=4.3,12.4Hz, 2H). The high resolution mass spectrometry (HRMS) (ESI) [M+H]+ calculated value of C14H18O3N2 was 263.1390 and the measured value was 263.1390.
References
[1] Patent: US2013/324551, 2013, A1. Location in patent: Paragraph 0314; 0315; 0316; 0317
[2] Patent: US5607944, 1997, A
Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
Benzyl 4-(aminocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aizikang Pharmaceutical Research Co., Ltd | 18721109360 | 306685371@qq.com | China | 1976 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
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