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Irsogladine

Irsogladine Structure
Irsogladine structure
CAS No.
57381-26-7
Chemical Name:
Irsogladine
Synonyms
Isoladine;Irsogladin;IRSOGLADINE;Irosgladine;Dicloguamine;Irsogladine free base;Irsogladine USP/EP/BP;Irsogladine, 10 mM in DMSO;2',5'-Dichlorobenzoguanamine;5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-3
CBNumber:
CB7767928
Molecular Formula:
C9H7Cl2N5
Molecular Weight:
256.09
MDL Number:
MFCD00866871
MOL File:
57381-26-7.mol
MSDS File:
SDS
Last updated:2026-01-20 10:51:09
Product description Number Pack Size Price
Irsogladine B1593 50mg $40
Irsogladine B1593 10mM(in 1mL DMSO) $50
Irsogladine 99.80% CS-2368 500mg $50
IRSOGLADINE 95.00% API0007238 25MG $141.75
Irsogladine C762 500mg $282
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Irsogladine Properties

Melting point 268-269°C
Boiling point 552.2±60.0 °C(Predicted)
Density 1.572
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility insoluble in H2O; insoluble in EtOH; ≥12.80 mg/mL in DMSO
pka 3.88±0.10(Predicted)
form solid
color White to off-white
CAS DataBase Reference 57381-26-7(CAS DataBase Reference)
FDA UNII QBX79NZC1D

Irsogladine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology B1593 Irsogladine 57381-26-7 50mg $40 2021-12-16 Buy
ApexBio Technology B1593 Irsogladine 57381-26-7 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ChemScene CS-2368 Irsogladine 99.80% 57381-26-7 500mg $50 2021-12-16 Buy
American Custom Chemicals Corporation API0007238 IRSOGLADINE 95.00% 57381-26-7 25MG $141.75 2021-12-16 Buy
AK Scientific C762 Irsogladine 57381-26-7 500mg $282 2021-12-16 Buy
Product number Packaging Price Buy
B1593 50mg $40 Buy
B1593 10mM(in 1mL DMSO) $50 Buy
CS-2368 500mg $50 Buy
API0007238 25MG $141.75 Buy
C762 500mg $282 Buy

Irsogladine Chemical Properties,Uses,Production

Uses

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

Definition

ChEBI: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine is a dichlorobenzene.

Biological Activity

irsogladine is a pde4 inhibitor and muscarinic acetylcholine receptor binder.irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (p < 0.02, p < 0.001), in tpa-deficient mic

Synthesis

Irsogladine maleate

84504-69-8

Irsogladine

57381-26-7

General procedure for the synthesis of 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine x maleate from 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine x maleate (0.3 g, 0.80 mmol) was dissolved in ethyl acetate ( 50 mL) and the reaction was stirred with saturated NaHCO3 solution (50 mL) for 1 hour at room temperature. After completion of the reaction, the organic layer was separated and washed with distilled water. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine in 70% yield.

IC 50

PDE4

References

[1] Ren, C.J., et al., Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res, 1998. 77(2): p. 126-31. DOI:10.1006/jsre.1998.5381
[2] Kawasaki, Y., et al., Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002. 25(4): p. 373-7. DOI:10.1097/00006676-200211000-00009
[3] Kyoi, T., et al., Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci, 2004. 75(15): p. 1833-42. DOI:10.1016/j.lfs.2004.03.022

Irsogladine synthesis

84504-69-8
57381-26-7
Synthesis of Irsogladine from Irsogladine maleate

Irsogladine Preparation Products And Raw materials

Raw materials

Dicyandiamide Ethanol Maleic acid Potassium hydroxide 2,5-DICHLOROTOLUENE
1,4-Dioxane Sulfamic acid 2,5-Dichlorobenzoic acid 2,5-Dichlorobenzonitrile Potassium permanganate
Irsogladine maleate

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Preparation Products

Irsogladine Suppliers

Global( 157)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7125 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Xiamen AmoyChem Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
SIMAGCHEM CORP 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Baoji Guokang Healthchem co.,ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from Irsogladine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Irsogladine pictures 2026-01-20 Irsogladine
57381-26-7
 US $29.00 / mg 99.74% 10g TargetMol Chemicals Inc.
Irsogladine pictures 2019-07-06 Irsogladine
57381-26-7
 US $7.00 / kg 1kg 99% 100KG Career Henan Chemical Co
  • Irsogladine pictures
  • Irsogladine
    57381-26-7
  • US $29.00 / mg
  • 99.74%
  • TargetMol Chemicals Inc.
  • Irsogladine pictures
  • Irsogladine
    57381-26-7
  • US $7.00 / kg
  • 99%
  • Career Henan Chemical Co

Irsogladine Spectrum

Irsogladine(57381-26-7)MSIrsogladine(57381-26-7)1HNMR

57381-26-7(Irsogladine)Related Search:

Diisopropylammonium dichloroacetate Iminodiacetonitrile Dichlorodimethylsilane 1,3,5-Triazine Iminodiacetic acid
Dichlorodiphenylsilane 4,4'-Methylenedianiline Irsogladine Impurity GDT Irsogladine Impurity TMSM2 Chlorobenzene
Famciclovir Irsogladine maleate IRSOGLADINE MALEATE Irsogladine 4-(4,6-Diamino-s-triazinyl)-2,5-dichlorophenol
3-(4,6-Diamino-s-triazinyl)-2,5-dichlorophenol 3-Pyridinecarboxamide, N-(4-(2,5-dichlorophenyl)-6-(1-piperidinyl)-1,3 ,5-triazin-2-yl)- 3-Pyridinecarboxamide, N-(4-(2,5-dichlorophenyl)-6-(4-morpholinyl)-1,3 ,5-triazin-2-yl)-

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5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-3 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine Irsogladin Irsogladine,2,4-DiaMino-6-(2,5-dichlorophenyl)-1,3,5-triazine IRSOGLADINE Irsogladine free base 2',5'-Dichlorobenzoguanamine Dicloguamine Irosgladine 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)- Irsogladine USP/EP/BP Isoladine Irsogladine, 10 mM in DMSO 57381-26-7 C9H7Cl2N5Q Active Pharmaceutical Ingredients pharmaceutical intermediates Inhibitors