UCF-101
- CAS No.
- 313649-08-0
- Chemical Name:
- UCF-101
- Synonyms
- UCF-101;UCF 101, 10 mM in DMSO;HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I;Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem;5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID;5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione;4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
- CBNumber:
- CB7773190
- Molecular Formula:
- C27H17N3O5S
- Molecular Weight:
- 495.51
- MDL Number:
- MFCD01000361
- MOL File:
- Mol file
| Boiling point | 651.8±65.0 °C(Predicted) |
|---|---|
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | -0.92±0.20(Predicted) |
| form | powder |
| color | light orange to dark orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H |
| InChIKey | NVNSXBXKNMWKEJ-UHFFFAOYSA-N |
| SMILES | C1(=S)N(C2=CC=CC=C2)C(=O)/C(=C\C2=CC=C(C3=CC=CC=C3[N+]([O-])=O)O2)/C(=O)N1C1=CC=CC=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
UCF-101 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1105 | UCF-101 ≥98% (HPLC) | 313649-08-0 | 5mg | $123 | 2025-07-31 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥98% | 313649-08-0 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥98% | 313649-08-0 | 5mg | $78 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1105 | UCF-101 ≥98% (HPLC) | 313649-08-0 | 25mg | $489 | 2025-07-31 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥98% | 313649-08-0 | 10mg | $138 | 2024-03-01 | Buy |
UCF-101 Chemical Properties,Uses,Production
Description
UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50?= 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50?≥ 200 μM).1?Mitigates streptozotocin-induced cardiomyocyte dysfunction.2?Protects against cerebral oxidative injury and cognitive impairment in a rat model.3? Cell permeable.
Uses
UCF 101 is a specific inhibitor of Omi/HtrA2, a proapoptotic mitochondrial serine protease. UCF 101 has the neuroprotective effects on cerebral oxidative injury and cognitive impairment in septic rats.
in vitro
ucf 101 was identified in a hts of a combinatorial library using omi-(134-458) protease and fluorescein-casein as a generic substrate. ucf 101 exhibited specific activity against omi/htra2 and very little activity against other serine proteases. ucf 101 showed a natural fluorescence that was used to monitor its ability to enter mammalian cells. in addition, when tested in caspase-9 (-/-) null fibroblasts, ucf 101 was able to inhibit omi/htra2-induced cell death [1].
in vivo
in a previous study, rats were intraperitoneally administered ucf-101 at 1.5 micromol/kg 10 min prior to reperfusion. results showed that ucf-101 treatment could significantly decrease cerebral infarct size by about 16.27% and also improve neurological behavior. moreover, ucf-101 treatment was able to reduce tunel-positive cells in the cerebral cortex significantly. in addition, the upregulation in the expression of fasl and the cleavage products of active caspase-3 and caspase-8 induced by ischemia was attenuated in mice treated with ucf-101, while upregulation of flip levels was increased [2].
IC 50
9.5 μm
References
[1] LUCIA CILENTI. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.[J]. The Journal of Biological Chemistry, 2003, 278 13: 11489-11494. DOI:10.1074/jbc.m212819200
[2] QUN LI Jun R Ji Li. UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK.[J]. American journal of physiology. Endocrinology and metabolism, 2009, 297 4: E965-73. DOI:10.1152/ajpendo.00323.2009
[3] YUEYU HU . Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat[J]. International immunopharmacology, 2013, 16 1: Pages 108-113. DOI:10.1016/j.intimp.2013.03.019
UCF-101 Preparation Products And Raw materials
Raw materials
Preparation Products
UCF-101 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32376 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4648 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
