UCF-101
|
- $40 - $1300
- Product name: UCF-101
- CAS: 313649-08-0
- MF: C27H17N3O5S
- MW: 495.51
- EINECS:
- MDL Number:MFCD01000361
- Synonyms:Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione;UCF-101;HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I;5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID;5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-
29 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101 ≥95%
- Packaging1mg
- Price$40
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging2mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging5mg
- Price$84
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging10mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging25mg
- Price$250
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging50mg
- Price$384
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007H6Q
- Product descriptionUCF-101
- Packaging100mg
- Price$545
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264472
- Product descriptionUCF 101 98%
- Packaging100MG
- Price$785
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD264472
- Product descriptionUCF 101 98%
- Packaging25MG
- Price$340
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM1034489
- Product description5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID 95.00%
- Packaging5MG
- Price$496.66
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4437
- Product descriptionUCF 101
- Packaging25mg
- Price$410
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4437
- Product descriptionUCF 101
- Packaging10mg
- Price$189
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC4437
- Product descriptionUCF 101
- Packaging5mg
- Price$128
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥95%
- Packaging10mg
- Price$152
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥95%
- Packaging5mg
- Price$86
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number15550
- Product descriptionUCF 101 ≥95%
- Packaging1mg
- Price$40
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007H6Q | UCF-101 ≥95% | 1mg | $40 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 2mg | $59 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 5mg | $84 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 10mg | $132 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 25mg | $250 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 50mg | $384 | 2026-05-28 | Buy |
| aablocks | AA007H6Q | UCF-101 | 100mg | $545 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264472 | UCF 101 98% | 100MG | $785 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD264472 | UCF 101 98% | 25MG | $340 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | CHM1034489 | 5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID 95.00% | 5MG | $496.66 | 2021-12-16 | Buy |
| ApexBio Technology | C4437 | UCF 101 | 25mg | $410 | 2026-05-06 | Buy |
| ApexBio Technology | C4437 | UCF 101 | 10mg | $189 | 2026-05-06 | Buy |
| ApexBio Technology | C4437 | UCF 101 | 5mg | $128 | 2026-05-06 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥95% | 10mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥95% | 5mg | $86 | 2026-04-30 | Buy |
| Cayman Chemical | 15550 | UCF 101 ≥95% | 1mg | $40 | 2026-04-30 | Buy |
Properties
Boiling point :651.8±65.0 °C(Predicted)
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :-0.92±0.20(Predicted)
form :powder
color :light orange to dark orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
InChIKey :NVNSXBXKNMWKEJ-UHFFFAOYSA-N
SMILES :C1(=S)N(C2=CC=CC=C2)C(=O)/C(=C\C2=CC=C(C3=CC=CC=C3[N+]([O-])=O)O2)/C(=O)N1C1=CC=CC=C1
Density :1.50±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :-0.92±0.20(Predicted)
form :powder
color :light orange to dark orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
InChIKey :NVNSXBXKNMWKEJ-UHFFFAOYSA-N
SMILES :C1(=S)N(C2=CC=CC=C2)C(=O)/C(=C\C2=CC=C(C3=CC=CC=C3[N+]([O-])=O)O2)/C(=O)N1C1=CC=CC=C1
Safety Information
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| Signal word: | Danger | ||||||||||||||||
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Description
Mammalian Omi/HtrA2 is a serine protease localized in mitochondria with close homology to bacterial HtrA chaperones. It is released from the mitochondria in response to apoptotic stimuli whereupon it induces cell death through both a caspase-dependent manner and a mechanism that involves its protease activity. UCF 101 is an inhibitor of the proteolytic activity of Omi/HtrA2 (IC50 = 9.5 μM). It is highly specific for Omi/HtrA2, demonstrating less potent activity when tested against a panel of various other serine proteases (IC50s range from 200 to >500 μM). Additionally, UCF 101 is naturally fluorescent, thus enabling the visualization of its entry into cells. UCF 101 has been used to decrease cerebral infarct size in a rat model of cerebral ischemia, demonstrating neuroprotective effects by reducing apoptosis of cortical cells. It has also been reported to be protective of cardiomyocytes against ischemic injury through a mechanism that prevents Omi/HtrA2 proteolysis of Thanatos-associated protein 5, a cardiac-specific nuclear protein that controls cell cycle progression.Related product price
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