2-Phenoxyethyl chloride
- CAS No.
- 622-86-6
- Chemical Name:
- 2-Phenoxyethyl chloride
- Synonyms
- NSC 1073;-Chlorophenetole;B-CHLOROPHENETOLE;á-chlorophenetole;β-chlorophenetole;?-chlorophenetole;PHENOXYETHYLCHLORIDE;OMEGA-CHLOROPHENETOL;BETA-CHLOROPHENETOLE;2-Phenoxyethyl chlor
- CBNumber:
- CB7775967
- Molecular Formula:
- C8H9ClO
- Molecular Weight:
- 156.61
- MDL Number:
- MFCD00018946
- MOL File:
- 622-86-6.mol
- MSDS File:
- SDS
| Melting point | 28°C |
|---|---|
| Boiling point | 97-98 °C15 mm Hg(lit.) |
| Density | 1.129 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 213 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform, Ethyl Acetate |
| form | Solid |
| color | Pale Yellow Oil to Low Melting Colorless |
| BRN | 971048 |
| InChI | 1S/C8H9ClO/c9-6-7-10-8-4-2-1-3-5-8/h1-5H,6-7H2 |
| InChIKey | VQUYNUJARXBNPK-UHFFFAOYSA-N |
| SMILES | ClCCOc1ccccc1 |
| CAS DataBase Reference | 622-86-6(CAS DataBase Reference) |
| FDA UNII | V283WU3KN8 |
| NIST Chemistry Reference | Benzene, (2-chloroethoxy)-(622-86-6) |
| EPA Substance Registry System | (2-Chloroethoxy)benzene (622-86-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 3265 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Phenoxyethyl chloride price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 114278 | (2-Chloroethoxy)benzene 98% | 622-86-6 | 10ml | $74.3 | 2026-04-30 | Buy |
| TCI Chemical | C0240 | beta-Chlorophenetole >95.0%(GC) | 622-86-6 | 25mL | $83 | 2026-04-30 | Buy |
| TCI Chemical | C0240 | beta-Chlorophenetole >95.0%(GC) | 622-86-6 | 500mL | $817 | 2026-04-30 | Buy |
| TRC | TRC-P319625-5G | Phenyl 2-Chloroethyl Ether | 622-86-6 | 5g | $65 | 2026-06-03 | Buy |
| TRC | TRC-P319625-50G | Phenyl 2-Chloroethyl Ether | 622-86-6 | 50g | $281 | 2026-06-03 | Buy |
2-Phenoxyethyl chloride Chemical Properties, Uses, Production
Chemical Properties
Pale Yellow Oil
Uses
Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.
Uses
(2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives.
Synthesis
122-99-6
622-86-6
At room temperature, 2.5 mL of N-methylpyrrolidone (NMP), 1.38 g (10 mmol) of 2-phenoxyethanol and 1.5 mL (11 mmol) of benzenesulfonyl chloride were added to the reaction flask. The mixture was stirred well and then the reaction was continuously stirred at 100 °C for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently extracted by adding 30 mL of dichloromethane and 30 mL of water. The organic layer was separated and washed with saturated brine and dried over anhydrous sodium sulfate. Dichloromethane was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography to give 1.52 g of 2-chlorophenetole in colorless liquid form in 96.8% yield.
References
[1] Patent: CN106187674, 2016, A. Location in patent: Paragraph 0017; 0018
[2] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0232; 0233
[3] Patent: US5527816, 1996, A
[4] Chemical Research in Toxicology, 2000, vol. 13, # 1, p. 53 - 62
[5] Patent: CN106146450, 2016, A. Location in patent: Paragraph 0132; 0133; 0134
2-Phenoxyethyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Donghualituo Techonlogy Development Co.,Ltd. | 010-88425576 | sales@dhltchem.com | China | 793 | 59 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Latest Price from 2-Phenoxyethyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2-Phenoxyethyl chloride
622-86-6
|
1KG | 99%min | 10 tons | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2019-12-26 | 2-Phenoxyethyl chloride
622-86-6
|
$1.00 | 1KG | ≥98% | Career Henan Chemical Co |
-
- 2-Phenoxyethyl chloride
622-86-6
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Phenoxyethyl chloride
622-86-6
- $1.00
- ≥98%
- Career Henan Chemical Co
