AG 490
- CAS No.
- 134036-52-5
- Chemical Name:
- AG 490
- Synonyms
- AG 490;(E/Z)-AG490;TYRPHOSTIN B42;AG 490 USP/EP/BP;TYROPHOSTIN AG490;(E/Z)-Tyrphostin B42;AG 490, Tryphostin B42;(E/Z)-Tyrphostin AG490;TYRPHOSTIN AG 490, 99+%;AG490 (Synonyms: Tyrphostin AG490
- CBNumber:
- CB7779213
- Molecular Formula:
- C17H14N2O3
- Molecular Weight:
- 294.31
- MDL Number:
- MFCD00209833
- MOL File:
- 134036-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 215 |
|---|---|
| Boiling point | 615.2±55.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | ethanol: 5 mg/mL |
| form | solid |
| pka | 8.82±0.35(Predicted) |
| color | yellow |
| CAS DataBase Reference | 134036-52-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-50-25 |
| Safety Statements | 26-36-61-45 |
| WGK Germany | 1 |
| Hazard Note | Irritant/Keep Cold under -20C |
| HS Code | 2926907090 |
AG 490 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 658411 | AG490 InSolution, ≥98%, inhibitor of EGFR kinase autophosphorylation | 5mg | $79.9 | 2026-03-19 | Buy | |
| Usbiological | A0928-65 | AG 490 (Tyrphostin B42, N-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide) ~98% | 134036-52-5 | 25mg | $468 | 2026-06-03 | Buy |
| Biosynth | FC17241 | AG 490 | 134036-52-5 | 50mg | $327 | 2026-06-04 | Buy |
| ChemScene | CS-0028548 | (E/Z)-AG490 99.71% | 134036-52-5 | 5mg | $38 | 2026-06-04 | Buy |
| ChemScene | CS-0028548 | (E/Z)-AG490 99.71% | 134036-52-5 | 10mg | $65 | 2026-06-04 | Buy |
AG 490 Chemical Properties, Uses, Production
Chemical Properties
Pale Yellow-Green Crystal
Uses
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Uses
Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.
Definition
ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.
AG 490 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 858 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Changzhou Renaissance Chem Co. Ltd | 86-519-86202821 | China | 116 | 56 | |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 |
View Latest Price from AG 490 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | (E/Z)-AG490
134036-52-5
|
$1230.00 | 10g | TargetMol Chemicals Inc. |
-
- (E/Z)-AG490
134036-52-5
- $1230.00
- TargetMol Chemicals Inc.
