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NS-398

NS-398 Structure
NS-398 structure
CAS No.
123653-11-2
Chemical Name:
NS-398
Synonyms
NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;NS-398, 10 mM in DMSO;NS 398, COX-2 inhibitor
CBNumber:
CB1754593
Molecular Formula:
C13H18N2O5S
Molecular Weight:
314.36
MDL Number:
MFCD00882995
MOL File:
123653-11-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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NS-398 Properties

Melting point 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point 490.6±55.0 °C(Predicted)
Density 1.377±0.06 g/cm3(Predicted)
RTECS PB0473500
storage temp. Sealed in dry,Room Temperature
solubility DMSO: >5 mg/mL
form solid
pka 6.33±0.10(Predicted)
color off-white
InChI 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
InChIKey KTDZCOWXCWUPEO-UHFFFAOYSA-N
SMILES CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O
FDA UNII 9SP55KM2KS
UNSPSC Code 41121800
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HS Code  2935.90.9500
Storage Class 11 - Combustible Solids

NS-398 price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N194 NS-398 ≥98% (HPLC), solid 123653-11-2 5mg $319 2026-04-30 Buy
Sigma-Aldrich 349254 NS-398 A cell-permeable selective inhibitor of COX-2 123653-11-2 5mg $250 2026-04-30 Buy
TCI Chemical N1152 NS-398 123653-11-2 10MG $82 2026-04-30 Buy
TCI Chemical N1152 NS-398 123653-11-2 50MG $296 2026-04-30 Buy
Cayman Chemical 70590 NS 398 ≥98% 123653-11-2 5mg $55 2026-04-30 Buy
Product number Packaging Price Buy
N194 5mg $319 Buy
349254 5mg $250 Buy
N1152 10MG $82 Buy
N1152 50MG $296 Buy
70590 5mg $55 Buy

NS-398 Chemical Properties,Uses,Production

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Preparation Products And Raw materials

Raw materials

Preparation Products

Glyoxal Acrylamide

NS-398 Suppliers

Global( 205)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Syntechem Co.,Ltd info@syntechem.com China 12973 57
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Energy Chemical 61
Ascent Scientific 60
Adamas Reagent, Ltd. 59
Syntechem Co.,Ltd 57
BOC Sciences 65
Dalian Meilun Biotech Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61
TOKYO CHEMICAL INDUSTRY CO., LTD. 80

View Lastest Price from NS-398 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NS-398 pictures 2026-07-27 NS-398
123653-11-2
 $44.00-97.00 99.72% 10g TargetMol Chemicals Inc.
NS-398 pictures 2025-06-20 NS-398
123653-11-2
 $1.00-20.00 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
NS-398 pictures 2025-03-10 NS-398
123653-11-2
 $10.00-30.00 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
  • NS-398 pictures
  • NS-398
    123653-11-2
  • $44.00-97.00
  • 99.72%
  • TargetMol Chemicals Inc.
  • NS-398 pictures
  • NS-398
    123653-11-2
  • $1.00-20.00
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • NS-398 pictures
  • NS-398
    123653-11-2
  • $10.00-30.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

NS-398 Spectrum

NS-398(123653-11-2)1HNMR

123653-11-2(NS-398)Related Search:

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AG 490 TYRPHOSTIN A25 Roscovitine Potassium clavulanate Ancymidol
NS-398 3-Isopropoxyaniline N-(2-Methoxy-4-nitro-phenyl)-methanesulfonamide 4-Nitro-2-propoxy-phenylamine 4-Nitro methanesulfonanilide
4-nitro-o-phenetidine Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI) NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide)

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CS-2231 NS-398 (NS 398 NS-398 - CAS 123653-11-2 - Calbiochem NS-398 N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE NS-398 98% N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide Taisho NS 398 NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE NS NS Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]- NS-398 USP/EP/BP Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase mitochondrial complex I inhibitor mitochondrial complex III inhibitor glycolysis inhibitor NS 398, COX-2 inhibitor NS-398, 10 mM in DMSO N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide (ACI) 123653-11-2 123652-11-2 Cyclooxygenase (COX) Enzymes Cyclooxygenase Inhibitors Enzymes, Inhibitors, and Substrates Biochemicals and Reagents Cell Signaling Enzymes BioChemical Application Index Signalling NF-κB Signaling Lipid signaling