1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid
- CAS No.
- 1001754-59-1
- Chemical Name:
- 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid
- Synonyms
- 1-Boc-3-fluoropyrrolidine-3-carboxylic acid;1-Boc-3-fluoropyrrolidine-3-carboxylic acid - [F14430];1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid;1-[(tert-butoxy)carbonyl]-3-fluoropyrrolidine-3-carboxylic a...;1,3-Pyrrolidinedicarboxylic acid, 3-fluoro-, 1-(1,1-dimethylethyl) ester;3-FLUORO-1-[(2-METHYLPROPAN-2-YL)OXYCARBONYL]PYRROLIDINE-3-CARBOXYLIC ACID
- CBNumber:
- CB7787227
- Molecular Formula:
- C10H16FNO4
- Molecular Weight:
- 233.24
- MDL Number:
- MFCD08703174
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6507 | 1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic Acid min. 98.0 % | 1001754-59-1 | 200MG | $136 | 2026-04-30 | Buy |
| Matrix Scientific | 124086 | 1-Boc-3-fluoropyrrolidine-3-carboxylic acid | 1001754-59-1 | 100.00mg | $68 | 2026-05-18 | Buy |
| Matrix Scientific | 124086 | 1-Boc-3-fluoropyrrolidine-3-carboxylic acid | 1001754-59-1 | 250.00mg | $122 | 2026-05-18 | Buy |
| Matrix Scientific | 124086 | 1-Boc-3-fluoropyrrolidine-3-carboxylic acid | 1001754-59-1 | 1.00g | $268 | 2026-05-18 | Buy |
| Synthonix | F14430 | 1-Boc-3-fluoropyrrolidine-3-carboxylic acid 97.0% | 1001754-59-1 | 100mg | $80 | 2026-05-06 | Buy |
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid Chemical Properties,Uses,Production
Synthesis
942189-96-0
1001754-59-1
Step 3: 1-tert-butyl 3-methyl 3-fluoropyrrolidine-1,3-dicarboxylate (414.4 mg, 1.676 mmol) was dissolved in a 3:1 THF/MeOH solvent mixture (5.6 mL), and 2.0 M KOH aqueous solution (2.1 mL, 4.19 mmol) was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the organic solvent was removed by distillation under reduced pressure. The residue was diluted with 20% isopropanol/dichloromethane (IPA/DCM) mixed solvent and subsequently acidified to pH 3 with 1.0 M aqueous HCl. The resulting mixture was extracted twice with 20% IPA/DCM mixed solvent, the organic phases were combined, washed twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid ( 352.8 mg, 90.3% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ= 13.80 (s, 1H), 3.69-3.54 (m, 3H), 3.36-3.32 (m, 1H), 2.43-2.24 (m, 2H), 1.40 (s, 9H).
References
[1] Patent: WO2013/20062, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: WO2018/178041, 2018, A1. Location in patent: Page/Page column 116; 117
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1-(tert-Butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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