Ly93
- CAS No.
- 1883528-69-5
- Chemical Name:
- Ly93
- Synonyms
- Ly93;Ly93,Ly-93;SMS2-IN-Ly93;Ly93, 10 mM in DMSO;2-((2-Ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide;Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-;2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide
- CBNumber:
- CB78054633
- Molecular Formula:
- C21H20N2O2
- Molecular Weight:
- 332.4
- MDL Number:
- MFCD32067900
- MOL File:
- 1883528-69-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Ly93 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082022 | Ly93 99.85% | 1883528-69-5 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0082022 | Ly93 99.85% | 1883528-69-5 | 10mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0082022 | Ly93 99.85% | 1883528-69-5 | 25mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0082022 | Ly93 99.85% | 1883528-69-5 | 50mg | $812 | 2026-06-04 | Buy |
| ChemScene | CS-0082022 | Ly93 99.85% | 1883528-69-5 | 100mg | $1246 | 2026-06-04 | Buy |
Ly93 Chemical Properties, Uses, Production
Uses
Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1].
Biological Activity
Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].
in vivo
Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].
Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].
| Animal Model: | C57BL/6J mice[1]. |
| Dosage: | 100 mg/kg. |
| Administration: | I.G. (gavage) once daily for 7 days. |
| Result: | Significantly decreased the plasma SM levels compared with vehicle group. |
| Animal Model: | ApoE KO mice (eight-week-old)[1]. |
| Dosage: | 12.5 or 40 mg/kg. |
| Administration: | I.G. (gavage) once daily. |
| Result: | The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group. |
References
[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.
Ly93 Preparation Products And Raw materials
Raw materials
Preparation Products
Ly93 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-025-85560043 17301488900 | info@synzest.com | China | 9274 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
