Ontuxizumab
- CAS No.
- 946415-62-9
- Chemical Name:
- Ontuxizumab
- Synonyms
- MORAb-004;Ontuxizumab;Research Grade Ontuxizumab;Research Grade Ontuxizumab (DHJ61001)
- CBNumber:
- CB78080902
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 0M2XT000YC |
Ontuxizumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0629216 | Ontuxizumab 99.85% | 946415-62-9 | 1mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-0629216 | Ontuxizumab 99.85% | 946415-62-9 | 5mg | $1029 | 2026-06-04 | Buy |
| ChemScene | CS-0629216 | Ontuxizumab 99.85% | 946415-62-9 | 10mg | $1722 | 2026-06-04 | Buy |
| ChemScene | CS-0629216 | Ontuxizumab 99.85% | 946415-62-9 | 25mg | $3142 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1290208 | Ontuxizumab >95% | 100μg | $280 | 2026-05-06 | Buy |
Ontuxizumab Chemical Properties, Uses, Production
Uses
Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1].
in vivo
Ontuxizumab (50 mg/kg; i.v., 5 doses daily for 5 consecutive days) shows antitumor effects in human CD248 knock-in mice[1].
| Animal Model: | Human CD248 knock-in mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days |
| Result: | Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes. |
References
[1] Rybinski K, et al. Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature. Oncotarget. 2015 Sep 22;6(28):25429-40. DOI:10.18632/oncotarget.4559
Ontuxizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Ontuxizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5568 | 58 |
| Wanxin Biotechnology (Jiaxing) Co., LTD | 0573-83568680 18057391398 | 3956524501@qq.com | China | 1441 | 58 |
