L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]-
![L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- Structure](CAS/20210111/GIF/162166-80-5.gif)
- CAS No.
- 162166-80-5
- Chemical Name:
- L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]-
- Synonyms
- BMS189664;BMS 189664;BMS-189664;BMS189664,BMS 189664;L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]-
- CBNumber:
- CB78357909
- Molecular Formula:
- C22H34N6O4S
- Molecular Weight:
- 478.61
- MDL Number:
- MOL File:
- 162166-80-5.mol
- MSDS File:
- SDS
L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- Properties
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| pka | 9.49±0.40(Predicted) |
| FDA UNII | 6YOX5T89W0 |
L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- Chemical Properties, Uses, Production
Uses
BMS-189664 is a potent, selective, and orally active reversible inhibitor of a-thrombin, with an IC50 of 0.046 μM. BMS-189664 can be used for arterial and venous thrombosis research[1].
in vivo
BMS-189664 is efficacious at protecting mice from thrombin-induced lethality[1].
BMS-189664 (0.2 mg/kg, iv) inhibits arterial thrombosis in cynomolgus monkey models[1].
BMS-189664 (infused at 9, 25, and 100 mg/kg/min for 1 h to achieve 0.5, 2, and 6 mg/kg) inhibits venous thrombosis in cynomolgus monkey models[1].
The oral bioavailability of BMS-189664 based on the dose-normalized AUCs after oral and iv dosing was 15 and 17% in dogs and monkeys, respectively[1].
References
[1] Das J, et al. Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorg Med Chem Lett. 2002 Jan 7;12(1):45-9. DOI:10.1016/s0960-894x(01)00667-9
L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from L-Prolinamide, N-(methylsulfonyl)-D-phenylalanyl-N-[[1-(aminoiminomethyl)-4-piperidinyl]methyl]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | BMS-189664
162166-80-5
|
$1820.00-3100.00 | 10g | TargetMol Chemicals Inc. |
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- BMS-189664
162166-80-5
- $1820.00-3100.00
- TargetMol Chemicals Inc.
