methyl ibogamine-18-carboxylate
- CAS No.
- 467-77-6
- Chemical Name:
- methyl ibogamine-18-carboxylate
- Synonyms
- NSC 127490;Coronaridin;coronardine;methyl ibogamine;methyl ibogamine-18-carboxylate;Ibogamine-18-carboxylic acid methyl ester;(-)-Ibogamine-18-carboxylic acid methyl ester
- CBNumber:
- CB7912456
- Molecular Formula:
- C21H26N2O2
- Molecular Weight:
- 338.448
- MDL Number:
- MFCD11111278
- MOL File:
- 467-77-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Coronaridine ≥98% | CFN92859 | 5mg | $488 |
methyl ibogamine-18-carboxylate Chemical Properties,Uses,Production
Uses
Ibogamine-18-carboxylic Acid Methyl Ester (CAS# 467-77-6) is a useful research chemical compound. It is used in the biosynthesis of anti-addiction agent from iboga plant.
Definition
ChEBI: (-)-coronaridine is a monoterpenoid indole alkaloid with formula C21H26N2O2. It is isolated from the flowering plant genus, Tabernaemontana. It has a role as an antileishmanial agent, an antineoplastic agent, an apoptosis inducer and a plant metabolite. It is a monoterpenoid indole alkaloid, a methyl ester, an organic heteropentacyclic compound and an alkaloid ester. It is a conjugate base of a (-)-coronaridine(1+).
Biological Activity
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1]. Coronaridine (0-40 μM; 24 hours) is against non-cancer cells with IC50 values >40 μM. It agaisnt wnt-dependent cells with IC50 values of 10.4, 11.6 and 24.4 μM for SW480, HCT116 and DLD1cells, respectively[1].Coronaridine (0-40 μM; 24 hours) inhibits β-catenin expression, but the protein levels of p-β--catenin at Ser33, Ser37, and Thr41 and p-β-catenin at Ser 45 [p-b-catenin (S45)] are unchanged[1].In whole-cell patch clamp recordings,Catharanthine (1-300 μM) are respectively co-applied with GABA at concentrations corresponding to the EC30 value for each receptor subtype. Both congeners potentiated different GABAARs in a concentration-dependent manner[2].At higher concentrations, however, Catharanthine starts to inhibit GABA-activated currents due to the reduced amplitude and rebound current, where the threshold concentration depended on the receptor subtype (e.g., > 30 μM for hα1β2; > 100 μM for hα1β2γ2 and hα2β2γ2). The PAM activity of Catharanthine's are depended on the receptor subtype: hα1β2 (4.6±0.8 μM), >hα2β2γ2 (12.6±3.8 μM), hα1β2γ2 (14.4 ± 4.6 μM)[2].
References
[1]. Kensuke Ohishi, et al. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3937-40. [2]. Hugo R Arias, et al. Coronaridine congeners potentiate GABA A receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109930
methyl ibogamine-18-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
methyl ibogamine-18-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3590 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2993 | 55 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 86249 | 60 |
| Shanghai ChengShao Biological Technology Co., Ltd. | 021-61847300 13341622919 | shcss01@163.com | China | 4808 | 58 |
View Lastest Price from methyl ibogamine-18-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | methyl ibogamine
467-77-6
|
US $1.00-1.00 / KG | 1KG | 99% | 10000KG | Shaanxi Dideu Medichem Co. Ltd | |
|
|
2025-12-12 | Coronaridin
467-77-6
|
US $1.00-1.00 / KG | 1KG | 99% | 10000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- methyl ibogamine
467-77-6
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Coronaridin
467-77-6
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
