TC-2559 difumarate
- CAS No.
- 2454492-41-0
- Chemical Name:
- TC-2559 difumarate
- Synonyms
- CBNumber:
- CB79273024
- Molecular Formula:
- C16H22N2O5
- Molecular Weight:
- 322.36
- MDL Number:
- MOL File:
- 2454492-41-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
TC-2559 difumarate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0120627 | TC-2559 difumarate 98.4% | 2454492-41-0 | 1mg | $270 | 2026-06-04 | Buy |
| ChemScene | CS-0120627 | TC-2559 difumarate 98.4% | 2454492-41-0 | 5mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0120627 | TC-2559 difumarate 98.4% | 2454492-41-0 | 10mg | $1078 | 2026-06-04 | Buy |
| aablocks | AA02AP6Z | TC-2559 (difumarate) >98% | 2454492-41-0 | 1mg | $312 | 2026-06-02 | Buy |
| aablocks | AA02AP6Z | TC-2559 (difumarate) >98% | 2454492-41-0 | 5mg | $724 | 2026-06-02 | Buy |
TC-2559 difumarate Chemical Properties, Uses, Production
Uses
TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 μM. Antinociceptive effect[1][2].
Biological Activity
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.
in vivo
TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2].
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2].
| Animal Model: | Adult male mice (body weight 15-30 g) (formalin test)[2] |
| Dosage: | 1, 3, 10 mg/kg |
| Administration: | I.p. |
| Result: | Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses. |
| Animal Model: | Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2] |
| Dosage: | 0.3, 1, 3 mg/kg |
| Administration: | I.p. |
| Result: | Significantly reversed CCI induced the paw withdrawal threshold decreases. |
storage
Desiccate at RT
References
[1] Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55. DOI:10.1016/s0014-2999(00)00807-4
[2] Cheng LZ, et al. Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559. Mol Pain. 2011;7:56. Published 2011 Aug 4. DOI:10.1016/s0028-3908(03)00189-8
TC-2559 difumarate Preparation Products And Raw materials
Raw materials
Preparation Products
TC-2559 difumarate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Supplier | Advantage |
|---|---|
| Guangzhou Younan Technology Co., Ltd | 58 |
| RD International Technology Co., Limited | 58 |
| TargetMol Chemicals Inc. | 58 |
