4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo-
![4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo- Structure](CAS/20210305/GIF/862377-51-3.gif)
- CAS No.
- 862377-51-3
- Chemical Name:
- 4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo-
- Synonyms
- Cl-Necrostatin-1;4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo-
- CBNumber:
- CB79829409
- Molecular Formula:
- C13H12ClN3OS
- Molecular Weight:
- 293.77
- MDL Number:
- MOL File:
- 862377-51-3.mol
- MSDS File:
- SDS
| Melting point | 249-253 °C |
|---|---|
| Boiling point | 470.2±48.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 14 mg/ml,Ethanol: 3 mg/ml |
| form | A crystalline solid |
| pka | 9.20±0.40(Predicted) |
4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11656 | Cl-Necrostatin-1 ≥95% | 862377-51-3 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 11656 | Cl-Necrostatin-1 ≥95% | 862377-51-3 | 5mg | $250 | 2026-04-30 | Buy |
| Cayman Chemical | 11656 | Cl-Necrostatin-1 ≥95% | 862377-51-3 | 10mg | $470 | 2026-04-30 | Buy |
| ChemScene | CS-1243666 | Cl-Necrostatin-1 | 862377-51-3 | 1mg | $212 | 2026-06-04 | Buy |
| ChemScene | CS-1243666 | Cl-Necrostatin-1 | 862377-51-3 | 5mg | $636 | 2026-06-04 | Buy |
4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo- Chemical Properties, Uses, Production
Uses
Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].
Biological Activity
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1).1 It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 μM. It also inhibits TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling.2,3 Cl-Necrostatin-1 (2 μl of a 4 mM solution, i.c.v.) reduces infarct size when administered pre- and post-occlusion, or post-occlusion only, in a mouse model of middle cerebral artery occlusion (MCAO).
References
1.Degterev, A., Hitomi, J., Germscheid, M., et al.Identification of RIP1 kinase as a specific cellular target of necrostatinsNat. Chem. Biol.4(5)313-321(2008) 2.Teng, X., Degterev, A., Jagtap, P., et al.Structure-activity relationship study of novel necroptosis inhibitorsBioorg. Med. Chem. Lett.15(22)5039-5044(2005) 3.Degterev, A., Huang, Z., Boyce, M., et al.Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injuryNat. Chem. Biol.1(2)112-119(2005)
4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo- Preparation Products And Raw materials
Raw materials
Preparation Products
4-Imidazolidinone, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2-thioxo- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
