2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
![2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide Structure](CAS/20180629/GIF/375835-43-1.gif)
- CAS No.
- 375835-43-1
- Chemical Name:
- 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
- Synonyms
- nec-34;Necrostatin-34;Necrostatin-34 (Nec-34);Necrostatin-34, 10 mM in DMSO;Necrostatin-34 (Nec-34) ，E0301;2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4;2-((3-Cyano-6-oxo-4-(p-tolyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide;Acetamide, 2-[[3-cyano-1,4,5,6-tetrahydro-4-(4-methylphenyl)-6-oxo-2-pyridinyl]thio]-N-2-thiazolyl-;2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide;Necrostatin 34,RIP kinase,FADD,Necrostatin-34,RIPK,inhibit,RIPK1,Receptor-interacting protein kinases,p-S166,Necroptosis,Necrostatin34,Inhibitor
- CBNumber:
- CB23991877
- Molecular Formula:
- C18H16N4O2S2
- Molecular Weight:
- 384.48
- MDL Number:
- MFCD02241236
- MOL File:
- 375835-43-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide Properties
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 125 mg/mL (325.11 mM; Need ultrasonic) |
| form | Solid |
| pka | 8.37±0.50(Predicted) |
| color | Off-white to light yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37735 | Necrostatin-34 ≥98% | 375835-43-1 | 1mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 37735 | Necrostatin-34 ≥98% | 375835-43-1 | 5mg | $300 | 2026-04-30 | Buy |
| Cayman Chemical | 37735 | Necrostatin-34 ≥98% | 375835-43-1 | 10mg | $531 | 2026-04-30 | Buy |
| Cayman Chemical | 37735 | Necrostatin-34 ≥98% | 375835-43-1 | 25mg | $1077 | 2026-04-30 | Buy |
| Biosynth | AQA83543 | Necrostatin-34 | 375835-43-1 | 25mg | $1164.25 | 2026-06-04 | Buy |
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide Chemical Properties, Uses, Production
Uses
Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain[1].
Biological Activity
Necrostatin-34 (Nec-34), a RIPK1 kinase inhibitor, stabilizes RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain[1]. Necrostatin-34 (Nec-34) exhibits IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively[1].Necrostatin-34 (Nec-34, 10 μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation[1].Necrostatin-34 (Nec-34) may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase[1].
IC 50
RIPK1
References
[1]. Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9787 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2232176231@qq.com | China | 9996 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 13795461237 | zhuruyan@jskchem.com | China | 49221 | 58 |
View Latest Price from 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Necrostatin-34
375835-43-1
|
$30.00-103.00 | 98.66% | 10g | TargetMol Chemicals Inc. |
-
- Necrostatin-34
375835-43-1
- $30.00-103.00
- 98.66%
- TargetMol Chemicals Inc.
