Vasonatrin Peptide (VNP)
- CAS No.
- 141676-35-9
- Chemical Name:
- Vasonatrin Peptide (VNP)
- Synonyms
- Vasonatrin Peptide (VNP);Vasonatrin Peptide (VNP) Trifluoroacetate;H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH;GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22);L-Tyrosine, glycyl-L-leucyl-L-seryl-L-lysylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-seryl-L-methionyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-, cyclic (6→22)-disulfide
- CBNumber:
- CB7998982
- Molecular Formula:
- C124H198N36O36S3
- Molecular Weight:
- 2865.32
- MDL Number:
- MFCD00671451
- MOL File:
- 141676-35-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Vasonatrin Peptide (VNP) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FV108689 | Vasonatrin Peptide (VNP) trifluoroacetate salt | 141676-35-9 | 500ug | $900 | 2026-06-04 | Buy |
| Biosynth | FV108689 | Vasonatrin Peptide (VNP) trifluoroacetate salt | 141676-35-9 | 250ug | $900 | 2026-06-04 | Buy |
| Biosynth | FV108689 | Vasonatrin Peptide (VNP) trifluoroacetate salt | 141676-35-9 | 1000ug | $920 | 2026-06-04 | Buy |
| Biosynth | FV108689 | Vasonatrin Peptide (VNP) trifluoroacetate salt | 141676-35-9 | 2000ug | $1580 | 2026-06-04 | Buy |
| Biosynth | FV108689 | Vasonatrin Peptide (VNP) trifluoroacetate salt | 141676-35-9 | 5000ug | $3400 | 2026-06-04 | Buy |
Vasonatrin Peptide (VNP) Chemical Properties,Uses,Production
Uses
Vasonatrin Peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].
in vivo
Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats[3].
| Animal Model: | High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats[3] |
| Dosage: | 100 μg/kg |
| Administration: | I.v. ; 10 min before reperfusion |
| Result: | Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP). |
References
[1] Wei CM, et al. Vasonatrin peptide: a unique synthetic natriuretic and vasorelaxing peptide. J Clin Invest. 1993;92(4):2048-2052. DOI:10.1172/JCI116800
[2] Chen BY, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes. J Endocrinol Invest. 2011;34(10):742-746. DOI:10.3275/7727
[3] Shi Z, et al. Vasonatrin peptide attenuates myocardial ischemia-reperfusion injury in diabetic rats and underlying mechanisms. Am J Physiol Heart Circ Physiol. 2015;308(4):H281-H290. DOI:10.1152/ajpheart.00666.2014
Vasonatrin Peptide (VNP) Preparation Products And Raw materials
Raw materials
Preparation Products
Vasonatrin Peptide (VNP) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
