PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
- CAS No.
- 73634-68-1
- Chemical Name:
- PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
- Synonyms
- PYR-LYENKPRRPWIL;[D-TRP11]-NEUROTENSIN;GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-DTRP-ILE-LEU;PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu;PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH
- CBNumber:
- CB8100308
- Molecular Formula:
- C80H122N22O19
- Molecular Weight:
- 1695.96
- MDL Number:
- MFCD00076683
- MOL File:
- Mol file
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH Chemical Properties,Uses,Production
Uses
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].
in vivo
[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2].
References
[1] Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12. DOI:10.1016/0014-2999(80)90133-8
[2] Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH Preparation Products And Raw materials
Raw materials
Preparation Products
PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Forest chemical technology | +85295407470 | grant@forestchem.freeqiye.com | China | 755 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42943 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9979 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4800 | 58 |
