|
|
| | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH Basic information |
| Product Name: | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH | | Synonyms: | PYR-LYENKPRRPWIL;PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU;[D-TRP11]-NEUROTENSIN;GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-DTRP-ILE-LEU;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH;Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH | | CAS: | 73634-68-1 | | MF: | C80H122N22O19 | | MW: | 1695.96 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | Mol File |  |
| | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH Chemical Properties |
| storage temp. | -15°C | | Sequence | {Pyr}-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-{D-Trp}-Ile-Leu |
| | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH Usage And Synthesis |
| Uses | [D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2]. | | in vivo | [D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2]. | | References | [1] Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12. DOI:10.1016/0014-2999(80)90133-8
[2] Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9. |
| | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH Preparation Products And Raw materials |
|