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1-AMINO-2-METHYLNAPHTHALENE

1-AMINO-2-METHYLNAPHTHALENE structure

CAS No.: 2246-44-8

Chemical Name:: 1-AMINO-2-METHYLNAPHTHALENE

Synonyms: 2-Methylnaphthalen-1-amine;2-METHYLNAPHTHYLAMINE;2-methyl-1-naftylamin;2-methyl-1-naphthylamin;2-Methyl-1-naphtylamine;2-METHYL-1-NAPHTHYLAMINE;1-Amino-2-methylphthalene;1-Amino-2-methylnaphtalene;2-METHYL-1-NAPHTHALENAMINE;1-AMINO-2-METHYLNAPHTHALENE

CBNumber:: CB8103602

Molecular Formula:: C11H11N

Molecular Weight:: 157.21

MDL Number:: MFCD00059135

MOL File:: 2246-44-8.mol

MSDS File:: SDS

Last updated:2026-06-30 18:36:42

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1-AMINO-2-METHYLNAPHTHALENE Properties

Melting point	28-31 °C(lit.)
Boiling point	165 °C
Density	1.67
refractive index	n20/D 1.670
Flash point	28 °C
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	powder to lump to clear liquid
pka	4.78±0.10(Predicted)
color	White or Colorless to Brown
BRN	2042530
Stability	Light Sensitive
InChI	InChI=1S/C11H11N/c1-8-6-7-9-4-2-3-5-10(9)11(8)12/h2-7H,12H2,1H3
InChIKey	JMBLSGAXSMOKPN-UHFFFAOYSA-N
SMILES	C1(N)=C2C(C=CC=C2)=CC=C1C
CAS DataBase Reference	2246-44-8(CAS DataBase Reference)
FDA UNII	UEU388PI4W
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

26-36

WGK Germany

RTECS

QM3675000

HS Code

2921490090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

NFPA 704

	0
1		0

1-AMINO-2-METHYLNAPHTHALENE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	67960	2-Methyl-1-naphthylamine ≥98.0% (GC)	2246-44-8	10ml	$571	2026-04-30	Buy
TCI Chemical	A0917	1-Amino-2-methylnaphthalene >98.0%(GC)(T)	2246-44-8	5g	$90	2026-04-30	Buy
TCI Chemical	A0917	1-Amino-2-methylnaphthalene >98.0%(GC)(T)	2246-44-8	25g	$305	2026-04-30	Buy
TRC	TRC-A577025-5G	1-Amino-2-Methylnaphthalene	2246-44-8	5g	$239	2026-06-03	Buy
TRC	TRC-A577025-500MG	1-Amino-2-Methylnaphthalene	2246-44-8	500mg	$65	2026-06-03	Buy

Product number	Packaging	Price	Buy
67960	10ml	$571	Buy
A0917	5g	$90	Buy
A0917	25g	$305	Buy
TRC-A577025-5G	5g	$239	Buy
TRC-A577025-500MG	500mg	$65	Buy

1-AMINO-2-METHYLNAPHTHALENE Chemical Properties,Uses,Production

Uses

1-Amino-2-Methylnaphthalene is used in preparation of (Piperazinyl)pyridopyrimidinone derivatives as KRAS G12C inhibitor for treatment of KRAS G12C-related diseases.

Synthesis

2586-62-1

2246-44-8

General procedure for the synthesis of 1-bromo-2-methylnaphthalene from 1-bromo-2-methylnaphthalene: In an oven-dried vial (35x12 mm) fitted with a PTFE-sealed screw cap, a magnetic stir bar, ((+/-)-binap)Ni[P(OPh)3]2-2PhCH3 (39 mg, 25 μmol, 5 mol%), (+/-)- binap (15 mg, 25 μmol, 5 mol%) and the corresponding aryl halide (0.50 mmol, 1.0 equiv). Subsequently, the vial was transferred to an argon-filled glove box and NaOtBu (216 mg, 2.20 mmol, 4.40 eq.) and NH3 (0.5 M solution of 1,4-dioxane, 3.0 mL, 1.5 mmol, 3.0 eq.) were added sequentially. After sealing the reaction vial, it was removed from the glove box and placed in an oil bath preheated to 120 °C with stirring for 18 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with Et2O (15 mL) and washed sequentially with 1 M NaOH (10 mL) and H2O (10 mL). The organic layer was adsorbed on silica gel and purified by fast column chromatography (eluent: EtOAc/hexane or EtOAc/MeOH) to obtain the target product aniline analogs. Specifically for the synthesis of 2-methylnaphthalen-1-amine (19k), 1-bromo-2-methylnaphthalene (84 μL, 0.50 mmol) was used as the starting material according to the general method described above and purified by fast column chromatography (eluent: Hexane/EtOAc 90:10) to afford the dark orange oily target compound 19k (73 mg, 0.46 mmol, 93% yield). The spectral data were in agreement with those reported in the literature [64]: Rf 0.20 (hexane/EtOAc 90:10); 1H NMR (CDCl3, 500 MHz) δ 7.85-7.80 (2H, m, 2Ar-H), 7.50-7.43 (2H, m, 2Ar-H), 7.33 (1H, d, J = 8.3 Hz, Ar-H), 7.28 (1H, d, J = 8.3 Hz, Ar-H), 4.11 (2H, br s, NH2), 2.38 (3H, s, CH3); 13C NMR (CDCl3, 125 MHz) δ 139.0 (Ar-C), 133.2 (Ar-C), 129.4 (Ar-CH), 128.6 (Ar-CH), 124.92 (Ar-CH), 124.92 (Ar-CH), 128.6 (Ar-CH), 124.92 (Ar-CH), 128.6 (Ar-CH), 128.6 (Ar-CH), 128.6 (Ar-CH), 124.9 (Ar-CH) 124.92 (Ar-CH), 124.87 (Ar-CH), 123.4 (Ar-C), 120.3 (Ar-CH), 118.3 (Ar-CH), 116.3 (Ar-CH), 17.8 (CH3).

References

[1] Australian Journal of Chemistry, 2015, vol. 68, # 12, p. 1842 - 1853
[2] Journal of Organic Chemistry, 2010, vol. 75, # 14, p. 4887 - 4890

1-AMINO-2-METHYLNAPHTHALENE Preparation Products And Raw materials

Raw materials

1-BROMO-2-METHYLNAPHTHALENE 1,4-Dioxane Ammonia Sodium tert-butoxide 1.1'-Binaphthyl-2.2'-diphemyl phosphine

Preparation Products

3,3'-DIMETHYLNAPHTHIDINE

1-AMINO-2-METHYLNAPHTHALENE Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
chemdawn (Wuhan) Biotechnology Co., Ltd	18086025538	397959126@qq.com	China	178	58
Wuhan Naixing Optoelectronic Technology Co., Ltd.	13407122362	397959126@qq.com	China	206	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chembon Pharmaceutical Co., Ltd.	028-84252981 18583719936	sales@chembon.com.cn	China	854	64

Supplier	Advantage
chemdawn (Wuhan) Biotechnology Co., Ltd	58
Wuhan Naixing Optoelectronic Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Wuhan Chemwish Technology Co., Ltd	56
Beijing Ouhe Technology Co., Ltd	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chembon Pharmaceutical Co., Ltd.	64

View Lastest Price from 1-AMINO-2-METHYLNAPHTHALENE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1-AMINO-2-METHYLNAPHTHALENE 2246-44-8	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-06-30	1-AMINO-2-METHYLNAPHTHALENE 2246-44-8		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2026-06-30	1-AMINO-2-METHYLNAPHTHALENE 2246-44-8		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

1-AMINO-2-METHYLNAPHTHALENE
2246-44-8
$1.10
99.00%
Dideu Industries Group Limited

1-AMINO-2-METHYLNAPHTHALENE
2246-44-8
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

1-AMINO-2-METHYLNAPHTHALENE
2246-44-8
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

1-AMINO-2-METHYLNAPHTHALENE Spectrum

1-AMINO-2-METHYLNAPHTHALENE(2246-44-8)¹HNMR

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2-methyl-1-naftylamin 2-methyl-1-naphthylamin 1-AMINO-2-METHYLNAPHTHALENE 2-METHYL-1-NAPHTHALENAMINE 2-METHYL-1-NAPHTHYLAMINE 2-METHYLNAPHTHYLAMINE 1-AMINO-2-METHYLNAPHTHALENE 97+% 2-Methyl-1-aminonaphthalene 2-Methyl-1-naphtylamine 1-NaphthalenaMine, 2-Methyl- 1-Amino-2-methylnaphtalene 1-Amino-2-methylnaphthalene > 1-AMINO-2-METHYLNAPHTHALENE ISO 9001：2015 REACH 1-Amino-2-methylphthalene 2-Methylnaphthalen-1-amine 2246-44-8 C11 to C37 Amines Building Blocks Nitrogen Compounds Organic Building Blocks 1