2-Methoxy-5-(trifluoromethoxy)benzaldehyde
- CAS No.
- 145742-65-0
- Chemical Name:
- 2-Methoxy-5-(trifluoromethoxy)benzaldehyde
- Synonyms
- 2-Formyl-4-(trifluoromethoxy)anisole;2-Methoxy-5-(trifluoromethoxy)benzaldehyde;Benzaldehyde, 2-methoxy-5-(trifluoromethoxy)-;2-Methoxy-5-(trifluoromethoxy)benzaldehyde>2-Formyl-4-(trifluoromethoxy)anisole, 3-Formyl-4-methoxy-alpha,alpha,alpha-trifluoroanisole
- CBNumber:
- CB8104801
- Molecular Formula:
- C9H7F3O3
- Molecular Weight:
- 220.15
- MDL Number:
- MFCD04115958
- MOL File:
- 145742-65-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 20-25℃ |
|---|---|
| Boiling point | 247.9±35.0 °C(Predicted) |
| Density | 1.36 |
| refractive index | 1.475 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | clear liquid |
| color | Light orange to Yellow to Green |
| Sensitive | Air Sensitive |
| CAS DataBase Reference | 145742-65-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P280a-P305+P351+P338-P321-P332+P313-P337+P313-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
2-Methoxy-5-(trifluoromethoxy)benzaldehyde price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M1945 | 2-Methoxy-5-(trifluoromethoxy)benzaldehyde >98.0%(GC) | 145742-65-0 | 5g | $70 | 2026-04-30 | Buy |
| TCI Chemical | M1945 | 2-Methoxy-5-(trifluoromethoxy)benzaldehyde >98.0%(GC) | 145742-65-0 | 25g | $271 | 2021-12-16 | Buy |
| Biosynth | FM70452 | 2-Methoxy-5-(trifluoromethoxy)benzaldehyde | 145742-65-0 | 25g | $181.5 | 2026-06-04 | Buy |
| Biosynth | FM70452 | 2-Methoxy-5-(trifluoromethoxy)benzaldehyde | 145742-65-0 | 50g | $354 | 2026-06-04 | Buy |
| Biosynth | FM70452 | 2-Methoxy-5-(trifluoromethoxy)benzaldehyde | 145742-65-0 | 100g | $680 | 2026-06-04 | Buy |
2-Methoxy-5-(trifluoromethoxy)benzaldehyde Chemical Properties, Uses, Production
Synthesis
93249-62-8
74-88-4
145742-65-0
(Step 1) To a 25 mL round-bottomed flask was added 1.0 g (4.85 mmol) of 5-(trifluoromethoxy)salicylaldehyde, 8 mL of dimethylformamide (DMF), and 738 mg (5.34 mmol) of potassium carbonate, and the mixture was stirred at room temperature for 30 min. Subsequently, 758 mg (5.34 mmol) of iodomethane dissolved in 2 mL of DMF was slowly added dropwise to the reaction system under ice bath cooling conditions. After the dropwise addition, stirring was continued under ice bath conditions for 1 h. The ice bath was then withdrawn and the reaction mixture was allowed to stir for 19 h at room temperature. Upon completion of the reaction, 20 mL of ethyl acetate and 20 mL of water were added to the mixture and the organic layer was separated by shaking thoroughly. The aqueous layer was extracted again with 20 mL of ethyl acetate and all organic layers were combined. The organic phase was sequentially washed twice with 20 mL of water and then twice with 20 mL of saturated saline. Finally, the organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1.0 g of 2-methoxy-5-(trifluoromethoxy)benzaldehyde in 93% yield. The product was characterized by 1H-NMR (CDCl3): δ 3.96 (s, 3H), 7.02 (d, 1H, J = 8.8 Hz), 7.41 (d, 1H, J = 9.2 Hz), 7.69 (s, 1H), 10.44 (s, 1H).
References
[1] Patent: EP1460062, 2004, A1. Location in patent: Page 70
2-Methoxy-5-(trifluoromethoxy)benzaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
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