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Cyclo(Arg-Gly-Asp-D-Phe-Val)

Cyclo(Arg-Gly-Asp-D-Phe-Val) Structure
Cyclo(Arg-Gly-Asp-D-Phe-Val) structure
CAS No.
137813-35-5
Chemical Name:
Cyclo(Arg-Gly-Asp-D-Phe-Val)
Synonyms
cRGDfV;EMD 66203;CYCLO(RGDD-FV);cyclo(RGD-DPhe-V);EMD 66203, c(RGDfV);RGDFV PEPTIDE, CYCLIC;Cyclo(Arg-Gls-Asp-D-Phe-Val);Cyclo(Arg-Gly-Asp-D-Phe-Val);Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt;Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl)
CBNumber:
CB8106724
Molecular Formula:
C26H38N8O7
Molecular Weight:
574.63
MDL Number:
MFCD00274410
MOL File:
137813-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:11
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Cyclo(Arg-Gly-Asp-D-Phe-Val) Properties

Density 1.45±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility 1 N acetic acid: 5mg/mL
form White solid
pka 4.01±0.10(Predicted)
color white
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

Cyclo(Arg-Gly-Asp-D-Phe-Val) price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 182015 Cyclo(Arg-Gly-Asp-D-Phe-Val) Potent inhibitor of cell adhesion. 137813-35-5 1mg $255 2026-04-30 Buy
Biosynth ICA-4304-V Cyclo(Arg-Gly-Asp-D-Phe-Val) 137813-35-5 0.5mg $301.55 2026-06-04 Buy
Biosynth ICA-4304 Cyclo(Arg-Gly-Asp-D-Phe-Val) 137813-35-5 25mg $2472 2026-06-04 Buy
Biosynth FC108714 Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt 137813-35-5 1mg $247.55 2026-06-04 Buy
Biosynth FC108714 Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt 137813-35-5 2mg $430.72 2026-06-04 Buy
Product number Packaging Price Buy
182015 1mg $255 Buy
ICA-4304-V 0.5mg $301.55 Buy
ICA-4304 25mg $2472 Buy
FC108714 1mg $247.55 Buy
FC108714 2mg $430.72 Buy

Cyclo(Arg-Gly-Asp-D-Phe-Val) Chemical Properties, Uses, Production

Uses

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1].

General Description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Biochem/physiol Actions

Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates

References

[1] Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. DOI:10.3892/ol.2016.5042

Cyclo(Arg-Gly-Asp-D-Phe-Val) Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclo(Arg-Gly-Asp-D-Phe-Val) Suppliers

Global Suppliers ( 92)
Supplier Tel Email Country ProdList Advantage
Alabiochem Tech.Co., Ltd. 512-58900862 400-0707518 sales@alabiochem.com China 988 59
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1010 55
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Hangzhou Peptide Biochem Co.,Ltd 0571-89197072; 18668118770 linda@peptide-china.com China 233 56
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9170 60
Creative Peptides info@creative-peptides.com United States 6083 56
Alabiotech Inc. 001-619-354-5251 sales@alabiotech-e.com United States 972 60
Supplier Advantage
Alabiochem Tech.Co., Ltd. 59
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Cellmano Biotech Limited 55
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Hangzhou Peptide Biochem Co.,Ltd 56
Alfa Chemistry 60
Creative Peptides 56
Alabiotech Inc. 60

View Latest Price from Cyclo(Arg-Gly-Asp-D-Phe-Val) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CYCLO(ARG-GLY-ASP-D-PHE-VAL) pictures 2025-04-04 CYCLO(ARG-GLY-ASP-D-PHE-VAL)
137813-35-5
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
CYCLO(ARG-GLY-ASP-D-PHE-VAL) pictures 2020-02-14 CYCLO(ARG-GLY-ASP-D-PHE-VAL)
137813-35-5
 $7.00 1KG 99% 100kg Career Henan Chemical Co

137813-35-5 (Cyclo(Arg-Gly-Asp-D-Phe-Val)) Related Search:

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RGDFV PEPTIDE, CYCLIC Cyclo(Arg-Gls-Asp-D-Phe-Val) EMD 66203, c(RGDfV) CYCLO(RGDD-FV) Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt Cyclo(Arg-Gly-Asp-D-Phe-Val) - CAS 137813-35-5 - Calbiochem cRGDfV EMD 66203 Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) cyclo(RGD-DPhe-V) 2-((2S,5R,8S,11S)-5-Benzyl-11-(3-guanidinopropyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Cyclo(Arg-Gly-Asp-D-Phe-Val) 137813-35-5 C26H38N8O7 Peptides Other Peptides Biochemicals and Reagents Amino Acids and Peptides BioChemical