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Dizocilpine

Dizocilpine Structure
Dizocilpine structure
CAS No.
77086-21-6
Chemical Name:
Dizocilpine
Synonyms
C13737;Dizocilpine;MK-801 (Dizocilpine);Dizocilpine (MK-801);Dizocilpine USP/EP/BP;Dizocilpine free base;Dizocilpine, 10 mM in DMSO;Dizocilpine free base(MK801);(5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine;(5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
CBNumber:
CB81075436
Molecular Formula:
C16H15N
Molecular Weight:
221.3
MDL Number:
MFCD06412575
MOL File:
77086-21-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Dizocilpine Properties

Melting point 68.5-69°
alpha 20589 +161.4° (c = 0.038 g/2 ml ethanol)
Boiling point 320.3±11.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
solubility Soluble in DMSO > 10 mM
form Powder
pka 7.96±0.40(Predicted)
color White to off-white
FDA UNII 7PY8KH681I
EPA Substance Registry System 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- (77086-21-6)

SAFETY

Risk and Safety Statements

Hazardous Substances Data 77086-21-6(Hazardous Substances Data)

Dizocilpine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth CDA08621 Dizocilpine 77086-21-6 5mg $900 2026-06-04 Buy
Biosynth CDA08621 Dizocilpine 77086-21-6 2mg $900 2026-06-04 Buy
Biosynth CDA08621 Dizocilpine 77086-21-6 25mg $900 2026-06-04 Buy
Biosynth CDA08621 Dizocilpine 77086-21-6 1mg $900 2026-06-04 Buy
Biosynth CDA08621 Dizocilpine 77086-21-6 10mg $900 2026-06-04 Buy
Product number Packaging Price Buy
CDA08621 5mg $900 Buy
CDA08621 2mg $900 Buy
CDA08621 25mg $900 Buy
CDA08621 1mg $900 Buy
CDA08621 10mg $900 Buy

Dizocilpine Chemical Properties, Uses, Production

Uses

Neuroprotective.

Definition

ChEBI: Dizocilpine is an organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory. It has a role as a NMDA receptor antagonist, an anaesthetic, an anticonvulsant, a nicotinic antagonist and a neuroprotective agent. It is a secondary amino compound and a tetracyclic antidepressant. It is a conjugate base of a dizocilpine(1+).

in vivo

Dizocilpine maleate can be used to create schizophrenia models. An intraperitoneal injection of 0.2 mg/kg in SD rats results in a half-life of 52.31 minutes, an AUC of 3185.48 nM·min, and a clearance rate of 34 mL/min/kg[2].

Induction of Schizophrenia
Background
The specific mechanism of schizophrenia induction is unclear. One hypothesis is that, Dizocilpine maleateleads to dysregulation of glutamatergic system through NMDA inhibition[2].
Specific Modeling Methods
Rat: Sprague-Dawley male adult with weight of 250-300 g
Administration: 0.4 mg/kg i.p. single dose.
Note
Dizocilpine maleate is dissolved in 0.9% sterile saline.
Modeling Indicators
Behavior: Increased spontaneous activity with obvious anxiety-like behavior, increased motor activity in longer diatance (hyperactivity), reduced time staying in central area (avoidance of central area).
Prepulse Inhibition (PPI): Decreased PPI significantly.
maze test:Avoided open arm entries in elevated plus maze test and reduced number of novel arm entries in Y maze test.
Correlated Product(s): Phencyclidine
Opposite Product(s): Clozapine (HY-14539); Haloperidol (HY-14538)

IC 50

NMDA Receptor

Dizocilpine synthesis

380427-51-0
77086-21-6
Synthesis of Dizocilpine from 5H-Dibenzo[a,d]cyclohepten-5,10-imine-5-methanol, 10,11-dihydro-, (5S,10R)-

Dizocilpine Preparation Products And Raw materials

Raw materials

5H-Dibenzo[a,d]cyclohepten-5,10-imine, 5-(bromomethyl)-10,11-dihydro-, (5S,10R)- 5H-Dibenzo[a,d]cyclohepten-5,10-imine-12-carboxylic acid, 5-cyano-10,11-dihydro-, ethenyl ester, (5S,10R)- 5H-Dibenzo[a,d]cyclohepten-5,10-imine-5-methanol, 10,11-dihydro-, (5S,10R)-

Preparation Products

Dizocilpine Suppliers

Global Suppliers ( 86)
Supplier Tel Email Country ProdList Advantage
Wuhan Topule +86-02787215551 19945035818 2936752263@qq.com China 7983 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101 1276242629@qq.com China 9977 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Target molecule Corp. 857-239-0968 service1@targetmol.com United States 2548 60
Chengdu Huachun Technology Co., Ltd 400-1166-196 15982826727 cdhxsj@163.com China 14571 60
Supplier Advantage
Wuhan Topule 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Macklin Biochemical Co.,Ltd. 55
Hubei Jusheng Technology Co.,Ltd 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Synchem Pharma Co., ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Target molecule Corp. 60
Chengdu Huachun Technology Co., Ltd 60

View Latest Price from Dizocilpine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dizocilpine pictures 2026-07-27 Dizocilpine
77086-21-6
 $35.00-113.00 99.98% 10g TargetMol Chemicals Inc.
Dizocilpine pictures 2020-02-06 Dizocilpine
77086-21-6
 $1.00 1KG 99%HPLC 100KG Career Henan Chemical Co
  • Dizocilpine pictures
  • Dizocilpine
    77086-21-6
  • $35.00-113.00
  • 99.98%
  • TargetMol Chemicals Inc.
  • Dizocilpine pictures
  • Dizocilpine
    77086-21-6
  • $1.00
  • 99%HPLC
  • Career Henan Chemical Co

Dizocilpine Spectrum

Dizocilpine(77086-21-6)1HNMR

77086-21-6 (Dizocilpine) Related Search:

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(5S)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5α,10α-imine [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine [5S,10R,(+)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5α,10α-imine C13737 MK-801 (Dizocilpine) 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)- Dizocilpine Dizocilpine free base(MK801) Dizocilpine USP/EP/BP Dizocilpine (MK-801) noncompetitive,MK 801,Dizocilpine,Ionotropic glutamate receptors,voltage,inhibit,MK801,hyperlocomotion,Inhibitor,iGluR,ambulation,neurotransmitter,anticonvulsant Dizocilpine free base (5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene Dizocilpine, 10 mM in DMSO 77086-21-6 Inhibitors