ChemicalBook >> CAS DataBase List >>(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid structure

CAS No.: 136696-10-1

Chemical Name:: (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid

Synonyms: 12-Oxo-ltb4;12-oxoleukotriene B4;12-Keto-leukotriene B4;12-dehydro-leukotriene B4;SJVWVCVZWMJXOK-NOJHDUNKSA-N;12-oxo Leukotriene B4 in acetonitrile, CAS 136696-10-1;(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-;6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-

CBNumber:: CB81235331

Molecular Formula:: C20H30O4

Molecular Weight:: 334.45

MDL Number:: MFCD00065854

MOL File:: 136696-10-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-17 09:03:53

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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Properties

Boiling point	524.2±50.0 °C(Predicted)
Density	1.036±0.06 g/cm3(Predicted)
storage temp.	Store at -80°C,protect from light
solubility	DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): > 1 mg/ml
pka	4.66±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

NFPA 704

	3
2		0

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20140	12-oxo Leukotriene B4 ≥90%	136696-10-1	10μg	$117	2026-04-30	Buy
Cayman Chemical	20140	12-oxo Leukotriene B4 ≥90%	136696-10-1	25μg	$245	2026-04-30	Buy
Cayman Chemical	20140	12-oxo Leukotriene B4 ≥90%	136696-10-1	50μg	$456	2026-04-30	Buy
Cayman Chemical	20140	12-oxo Leukotriene B4 ≥90%	136696-10-1	100μg	$796	2026-04-30	Buy
ChemScene	CS-0108362	12-Oxo-leukotriene B4	136696-10-1	10μg	$252	2026-06-04	Buy

Product number	Packaging	Price	Buy
20140	10μg	$117	Buy
20140	25μg	$245	Buy
20140	50μg	$456	Buy
20140	100μg	$796	Buy
CS-0108362	10μg	$252	Buy

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Chemical Properties, Uses, Production

Description

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB₄ is an initial metabolite of LTB₄ formed via the LTB₄ 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB₄, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB₄. 12-oxo-LTB₄ (EC₅₀ = 33 nM) is about 70-fold less potent than LTB₄ (EC₅₀ = 0.46 nM) at stimulating Ca²⁺ mobilization in human neutrophils. It is also significantly less potent than LTB₄ at stimulating neutrophil migration with EC₅₀ values of 170 and 2.7 nM for 12-oxo-LTB₄ and LTB₄, respectively.

Uses

12-oxo Leukotriene B4 in acetonitrile is a potent eicosanoid lipid mediators.

Definition

ChEBI: A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.

References

[1] T. YOKOMIZO. Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase.[J]. The Journal of Biological Chemistry, 1993, 292 1: 18128-18135. DOI: 10.1016/s0021-9258(17)46820-7
[2] S. WAINWRIGHT W P. Mechanism for the formation of dihydro metabolites of 12-hydroxyeicosanoids. Conversion of leukotriene B4 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid to 12-oxo intermediates.[J]. The Journal of Biological Chemistry, 1991, 43 1: 20899-20906. DOI: 10.1016/s0021-9258(18)54795-5
[3] P WHEELAN. Metabolism of leukotriene B4 by cultured human keratinocytes. Formation of glutathione conjugates and dihydro metabolites.[J]. The Journal of Biological Chemistry, 1993, 268 34: 25439-25448.
[4] W S POWELL. Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 276 2: 728-736.

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Suppliers

Global Suppliers ( 14)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6705	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44871	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7982	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11963	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Hongye Biotechnology Co. Ltd	58
TargetMol Chemicals Inc.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

View Latest Price from (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-17	12-oxo Leukotriene B4 136696-10-1	$554.00			10g	TargetMol Chemicals Inc.

12-oxo Leukotriene B4
136696-10-1
$554.00
TargetMol Chemicals Inc.

136696-10-1 ((5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid) Related Search:

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid 2,4-HEPTADIEN-6-ONE 6,8,10,14-Eicosatetraenoic acid, 12-hydroxy-5-oxo-, (6Z,8E,10E,12R,14Z)- Leukotriene B4-d5 14,15-Dehydro leukotriene B4

(5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid

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(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid 12-Keto-leukotriene B4 12-oxoleukotriene B4 12-Oxo-ltb4 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))- 12-dehydro-leukotriene B4 SJVWVCVZWMJXOK-NOJHDUNKSA-N 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)- 12-oxo Leukotriene B4 in acetonitrile, CAS 136696-10-1 136696-10-1