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ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy-

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy-

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- Structure
5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- structure
CAS No.
2339867-53-5
Chemical Name:
5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy-
Synonyms
PHD2/HDACs-IN-1;5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy-
CBNumber:
CB812897489
Molecular Formula:
C18H19N9O4
Molecular Weight:
425.4
MDL Number:
MOL File:
2339867-53-5.mol
MSDS File:
SDS
Last updated:2026-04-21 10:31:43
Request For Quotation

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- Properties

Density 1.68±0.1 g/cm3(Predicted)
pka 5.72±0.50(Predicted)

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- Chemical Properties, Uses, Production

Uses

PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC50s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI)[1].

in vivo

PHD2/HDACs-IN-1 (10 mg/kg/day; i.p.; 2 days) has significant renal protecting effects on alleviating pathological injuries with considerably decreased tubular injury scores[1].

Animal Model:Male C57BL/6 mice (8 weeks; n=5) (Cisplatin-induced AKI)[1]
Dosage:10 mg/kg/day
Administration:i.p., 2 days
Result:Showed significant renal protecting effects on alleviating pathological injuries with considerably decreased tubular injury scores.

IC 50

HDAC1: 19.75 μM (IC50); HDAC2: 26.60 μM (IC50); HDAC6: 15.98 μM (IC50); PHD2: 1.15 μM (IC50)

References

[1] Wei H, et al. Novel PHD2/HDACs hybrid inhibitors protect against cisplatin-induced acute kidney injury. Eur J Med Chem. 2022;230:114115. DOI:10.1016/j.ejmech.2022.114115

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PHD2/HDACs-IN-1 pictures 2026-04-20 PHD2/HDACs-IN-1
2339867-53-5
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

2339867-53-5 (5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy-) Related Search:

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5-Pyrimidinecarboxamide, 2-[4-[[[1,6-dihydro-6-oxo-2-(1H-pyrazol-1-yl)-5-pyrimidinyl]carbonyl]amino]-1-piperidinyl]-N-hydroxy- PHD2/HDACs-IN-1 2339867-53-5