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1-(Bromomethyl)-4-(methylsulfonyl)benzene

1-(Bromomethyl)-4-(methylsulfonyl)benzene Structure
1-(Bromomethyl)-4-(methylsulfonyl)benzene structure
CAS No.
53606-06-7
Chemical Name:
1-(Bromomethyl)-4-(methylsulfonyl)benzene
Synonyms
4-(Methanesulfonyl)benzyl bromide;1-(Chloromethyl)-4-(methylsulfonyl)benzene;4-METHYLSULFONYLBENZYL BROMIDE;4-METHYLSULPHONYLBENZYL BROMIDE;4-(Methylsulfonyl)benzylBromide>4-Methylsulphonylbenzyl bromide,85%;4-Methylsulphonylbenzyl bromide, tech.;4-(Methylsulphonyl)benzyl bromide 97%;1-(broMoMethyl)-4-Methanesulfonylbenzene;1-(Bromomethyl)-4-(methylsulfonyl)benzene
CBNumber:
CB8132497
Molecular Formula:
C8H9BrO2S
Molecular Weight:
249.12
MDL Number:
MFCD00185849
MOL File:
53606-06-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:12
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1-(Bromomethyl)-4-(methylsulfonyl)benzene Properties

Melting point 82-86 °C
Boiling point 375.2±34.0 °C(Predicted)
Density 1.550
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form Crystalline Powder
color Beige to brown
InChI 1S/C8H9BrO2S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3
InChIKey HGKPAXHJTMHWAH-UHFFFAOYSA-N
SMILES CS(C1=CC=C(CBr)C=C1)(=O)=O
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P280-P301+P312+P330-P305+P351+P338-P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-36-22-34
Safety Statements  37/39-26-45-36/37/39
RIDADR  UN3261
WGK Germany  3
HazardClass  8
PackingGroup  III
HS Code  29049090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
2 0

1-(Bromomethyl)-4-(methylsulfonyl)benzene price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich VBP00037 4-(Methylsulfonyl)benzyl bromide Aldrich 53606-06-7 1g $197 2026-04-30 Buy
TCI Chemical M2474 4-(Methylsulfonyl)benzyl Bromide >97.0%(GC)(T) 53606-06-7 1g $67 2026-04-30 Buy
TCI Chemical M2474 4-(Methylsulfonyl)benzyl Bromide >97.0%(GC)(T) 53606-06-7 5g $228 2026-04-30 Buy
Activate Scientific AS20402 4-(Methylsulfonyl)benzyl Bromide 98% 53606-06-7 1g $35 2026-06-04 Buy
Activate Scientific AS20402 4-(Methylsulfonyl)benzyl Bromide 98% 53606-06-7 5g $84 2026-06-04 Buy
Product number Packaging Price Buy
VBP00037 1g $197 Buy
M2474 1g $67 Buy
M2474 5g $228 Buy
AS20402 1g $35 Buy
AS20402 5g $84 Buy

1-(Bromomethyl)-4-(methylsulfonyl)benzene Chemical Properties, Uses, Production

Chemical Properties

white to beige crystalline powder

Synthesis

4-(METHYLSULFONYL)BENZYL ALCOHOL

22821-77-8

1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE

53606-06-7

The general procedure for the synthesis of 4-(methylsulfonyl)benzyl bromide from 4-methylsulfonylphenylmethanol was as follows: methanesulfonyl chloride (1.00 mL, 12.9 mmol) was added slowly and dropwise to a stirred solution of 4-(methylsulfonyl)phenylmethanol (2.00 g, 10.7 mmol) and triethylamine (2.24 mL, 16.1 mmol) in acetone (25 mL) at 0 °C. The reaction mixture was continued to be stirred at this temperature for 30 minutes. The reaction mixture was filtered and lithium bromide (4.66 g, 53.7 mmol) was added to the filtrate in three batches at 0 °C. The resulting mixture was stirred at 0 °C for 5 minutes and then gradually warmed up to room temperature and continued stirring for 1.5 hours. The reaction mixture was filtered again and the filtrate was concentrated under vacuum. After dilution with 50 mL of water, the product was extracted with dichloromethane (50 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under vacuum to give 1-(bromomethyl)-4-(methylsulfonyl)benzene (2.80 g, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3) δppm: 7.95 (d, J=8.4 Hz, 2H), 7.61 (d, J=8.4 Hz, 2H), 4.53 (s, 2H), 3.08 (s, 3H).

References

[1] Patent: WO2017/136871, 2017, A1. Location in patent: Paragraph 0223
[2] Journal of the Chemical Society, 1962, p. 1420 - 1427
[3] Canadian Journal of Chemistry, 1984, vol. 62, p. 2330 - 2336
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 1757 - 1763
[5] Journal of Organic Chemistry, 2011, vol. 76, # 20, p. 8203 - 8214

1-(Bromomethyl)-4-(methylsulfonyl)benzene Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide 1-Methyl-4-(methylsulfonyl)-benzene Carbon tetrachloride 4-(Methylsulfonyl)benzyl alcohol Methanesulfonyl chloride
Lithium bromide Triethylamine

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Preparation Products

1-(Bromomethyl)-4-(methylsulfonyl)benzene Suppliers

Global Suppliers ( 150)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Wujiang Suke Medical Technology Co., Ltd. +86-512-6320-2019 China 28 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Wujiang Suke Medical Technology Co., Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 1-(Bromomethyl)-4-(methylsulfonyl)benzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE pictures 2023-07-31 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
53606-06-7
 $10.00 1kg 99% 100000 Hebei Linwo New Material Technology Co., LTD
1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE pictures 2021-08-12 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
53606-06-7
 $48.00 1g 99.9% 500000kgs Shijiazhuang tongyang Import and Export Co., LTD
1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE pictures 2020-01-09 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
53606-06-7
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

1-(Bromomethyl)-4-(methylsulfonyl)benzene Spectrum

1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE(53606-06-7)1HNMR

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1-(bromomethyl)-4-[(4-methylphenyl)sulfonyl]benzene

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1-(Bromomethyl)-4-(methylsulfonyl)benzene [tech.] 4-Methylsulphonylbenzyl broMide, tech. 2.5GR 1-(broMoMethyl)-4-Methanesulfonylbenzene 1-(Bromomethyl)-4-(methylsulphonyl)benzene, 4-(Bromomethyl)phenyl methyl sulphone 4-(Methanesulfonyl)benzyl bromide 1-(Bromomethyl)-4-(methylsulfonyl)benzene 1-(Chloromethyl)-4-(methylsulfonyl)benzene 4-METHYLSULFONYLBENZYL BROMIDE 4-METHYLSULPHONYLBENZYL BROMIDE 4-Methylsulphonylbenzyl bromide, tech. 4-Methylsulphonylbenzyl bromide,85% 4-Methylsulphonylbenzyl bromide,75-80%,tech 4-(Methylsulphonyl)benzyl bromide 97% 4-(Methylsulfonyl)benzylBromide> Benzene, 1-(bromomethyl)-4-(methylsulfonyl)- 4-(Methanesulfonyl)benzyl bromide 1-(Bromomethyl)-4-(methylsulfonyl)benzene 53606-06-7 C8H9B2O2S BENZYL HALIDE Boron, Nitrile, Thio,& TM-Cpds Halides