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5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

CAS No.
757978-18-0
Chemical Name:
5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
Synonyms
Zinc04352700;5-Bromo-3-iodo-7-azaindole;5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-5-iodo-7H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-iodo-;5-Bromo-3-iodo-1H-pyrrolo(2,3-b)pyridine 97%
CBNumber:
CB8139289
Molecular Formula:
C7H4BrIN2
Molecular Weight:
322.93
MDL Number:
MFCD07779519
MOL File:
757978-18-0.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:54

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Properties

Melting point 234-239 °C
Boiling point 324℃
Density 2.52
Flash point 150℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form solid
pka 11.42±0.40(Predicted)
color Off-white to light yellow
Sensitive Light Sensitive
InChI InChI=1S/C7H4BrIN2/c8-4-1-5-6(9)3-11-7(5)10-2-4/h1-3H,(H,10,11)
InChIKey GIPGJYARDOQGDJ-UHFFFAOYSA-N
SMILES C12NC=C(I)C1=CC(Br)=CN=2
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
Hazard Codes  Xi,Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
NFPA 704
1
2 0

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 702307 5-Bromo-3-iodo-7-azaindole 97% 757978-18-0 1g $72.93 2025-07-31 Buy
TCI Chemical B6412 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 757978-18-0 1G $90 2025-07-31 Buy
TCI Chemical B6412 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 757978-18-0 5G $270 2025-07-31 Buy
TRC B694575 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 757978-18-0 50mg $60 2021-12-16 Buy
Matrix Scientific 020019 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 95% 757978-18-0 250mg $258 2021-12-16 Buy
Product number Packaging Price Buy
702307 1g $72.93 Buy
B6412 1G $90 Buy
B6412 5G $270 Buy
B694575 50mg $60 Buy
020019 250mg $258 Buy

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Uses,Production

Uses

5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine is a useful intermediate for organic synthesis.

Synthesis

5-Bromo-7-azaindole

183208-35-7

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

757978-18-0

General procedure for the synthesis of 5-bromo-3-iodo-7-azaindole from 5-bromo-7-azaindole: Preparation of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (Intermediate A) [0442]. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (10 g, 50.76 mmol) was dissolved in 500 mL of acetone with stirring, followed by the addition of N-iodosuccinimide. The reaction mixture was stirred at room temperature for 20 min. Upon completion of the reaction, the product was pulverized, the white solid was collected by filtration and washed with 100 mL of acetone. The resulting solid was dried under vacuum to afford 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (16.34 g, 100% yield) as a light yellow powder.1H NMR (DMSO-d6, 300 MHz) δ 8.51 (d, J = 2.1 Hz, 1H), 8.22 (s, 1H), 8.02 (d, J = 1.2 Hz, 1H), 8.00 (d, J = 5.1 Hz, 2H), 7.44 (dd, J = 8.7 Hz, 0.6 Hz, 2H), 2.35 (s, 3H); MS ESI (m/z): 322/324 [M + H]+, calculated value 322.

References

[1] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 162
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9569 - 9585
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0400
[4] Patent: US2015/307492, 2015, A1. Location in patent: Paragraph 0120-0125
[5] Patent: WO2016/26078, 2016, A1. Location in patent: Paragraph 076

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 191)Suppliers
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Capot Chemical Co.,Ltd.
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Hefei Hirisun Pharmatech Co., Ltd
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Dayang Chem (Hangzhou) Co.,Ltd.
+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58

View Lastest Price from 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE pictures 2019-09-11 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
757978-18-0
US $1.00 / g 1g 95%~99% per week 100kg Career Henan Chemical Co

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Spectrum

5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE 5-Bromo-3-iodo-7-azaindole Zinc04352700 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-iodo- 5-Bromo-3-iodo-1H-pyrrolo(2,3-b)pyridine 97% 3-Bromo-5-iodo-7H-pyrrolo[2,3-b]pyridine 757978-18-0 Iodide Heterocycle-Pyridine series