5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
- CAS No.
- 757978-18-0
- Chemical Name:
- 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
- Synonyms
- Zinc04352700;5-Bromo-3-iodo-7-azaindole;5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE;3-Bromo-5-iodo-7H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-iodo-;5-Bromo-3-iodo-1H-pyrrolo(2,3-b)pyridine 97%
- CBNumber:
- CB8139289
- Molecular Formula:
- C7H4BrIN2
- Molecular Weight:
- 322.93
- MDL Number:
- MFCD07779519
- MOL File:
- 757978-18-0.mol
- MSDS File:
- SDS
Melting point | 234-239 °C |
---|---|
Boiling point | 324℃ |
Density | 2.52 |
Flash point | 150℃ |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
form | solid |
pka | 11.42±0.40(Predicted) |
color | Off-white to light yellow |
Sensitive | Light Sensitive |
InChI | InChI=1S/C7H4BrIN2/c8-4-1-5-6(9)3-11-7(5)10-2-4/h1-3H,(H,10,11) |
InChIKey | GIPGJYARDOQGDJ-UHFFFAOYSA-N |
SMILES | C12NC=C(I)C1=CC(Br)=CN=2 |
UNSPSC Code | 12352100 |
NACRES | NA.22 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H315-H318-H335 | |||||||||
Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 22-37/38-41 | |||||||||
Safety Statements | 26-39 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
|
5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 702307 | 5-Bromo-3-iodo-7-azaindole 97% | 757978-18-0 | 1g | $72.93 | 2025-07-31 | Buy |
TCI Chemical | B6412 | 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine | 757978-18-0 | 1G | $90 | 2025-07-31 | Buy |
TCI Chemical | B6412 | 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine | 757978-18-0 | 5G | $270 | 2025-07-31 | Buy |
TRC | B694575 | 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine | 757978-18-0 | 50mg | $60 | 2021-12-16 | Buy |
Matrix Scientific | 020019 | 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine 95% | 757978-18-0 | 250mg | $258 | 2021-12-16 | Buy |
5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Uses,Production
Uses
5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine is a useful intermediate for organic synthesis.
Synthesis

183208-35-7
![5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE](/CAS/GIF/757978-18-0.gif)
757978-18-0
General procedure for the synthesis of 5-bromo-3-iodo-7-azaindole from 5-bromo-7-azaindole: Preparation of 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (Intermediate A) [0442]. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (10 g, 50.76 mmol) was dissolved in 500 mL of acetone with stirring, followed by the addition of N-iodosuccinimide. The reaction mixture was stirred at room temperature for 20 min. Upon completion of the reaction, the product was pulverized, the white solid was collected by filtration and washed with 100 mL of acetone. The resulting solid was dried under vacuum to afford 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (16.34 g, 100% yield) as a light yellow powder.1H NMR (DMSO-d6, 300 MHz) δ 8.51 (d, J = 2.1 Hz, 1H), 8.22 (s, 1H), 8.02 (d, J = 1.2 Hz, 1H), 8.00 (d, J = 5.1 Hz, 2H), 7.44 (dd, J = 8.7 Hz, 0.6 Hz, 2H), 2.35 (s, 3H); MS ESI (m/z): 322/324 [M + H]+, calculated value 322.
References
[1] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 162
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9569 - 9585
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0400
[4] Patent: US2015/307492, 2015, A1. Location in patent: Paragraph 0120-0125
[5] Patent: WO2016/26078, 2016, A1. Location in patent: Paragraph 076
5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers
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2019-09-11 | 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
757978-18-0
|
US $1.00 / g | 1g | 95%~99% | per week 100kg | Career Henan Chemical Co |
-
- 5-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
757978-18-0
- US $1.00 / g
- 95%~99%
- Career Henan Chemical Co
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