arborinine
- CAS No.
- 5489-57-6
- Chemical Name:
- arborinine
- Synonyms
- arborinine;1-Hydroxy-2,3-dimethoxy-10-methylacridin-9(10H)-one;9(10H)-Acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-
- CBNumber:
- CB81395499
- Molecular Formula:
- C16H15NO4
- Molecular Weight:
- 285.29
- MDL Number:
- MFCD00060475
- MOL File:
- 5489-57-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Arborinine ≥98% (HPLC) | SML3966 | 5 mg | $106 |
| Arborinine ≥98% (HPLC) | SML3966 | 25 mg | $428 |
| Arborinine ≥98% (HPLC) | SML3966 | 1 unit | $399 |
| Arborinine | XA163699 | 1mg | $95 |
| Arborinine | 8638CN | 1mg | $178 |
| Melting point | 177-177.5 °C |
|---|---|
| Boiling point | 508.4±50.0 °C(Predicted) |
| Density | 1.296±0.06 g/cm3(Predicted) |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| form | powder |
| pka | 7.29±0.20(Predicted) |
| color | white to beige |
| SMILES | O=C1C2=C(C=C(C(OC)=C2O)OC)N(C)C3=C1C=CC=C3 |
| FDA UNII | 16XG8UE639 |
| NACRES | NA.21 |
arborinine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3966 | Arborinine ≥98% (HPLC) | 5489-57-6 | 5 mg | $106 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3966 | Arborinine ≥98% (HPLC) | 5489-57-6 | 25 mg | $428 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3966 | Arborinine ≥98% (HPLC) | 5489-57-6 | 1 unit | $399 | 2025-07-31 | Buy |
| Biosynth Carbosynth | XA163699 | Arborinine | 5489-57-6 | 1mg | $95 | 2021-12-16 | Buy |
| AK Scientific | 8638CN | Arborinine | 5489-57-6 | 1mg | $178 | 2021-12-16 | Buy |
arborinine Chemical Properties,Uses,Production
Uses
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].
Definition
ChEBI: Arborinine is a member of acridines. It is functionally related to an acridone.
in vivo
Arborinine (40, 80 mg/kg; p.o.; for 21 days) shows antitumor activity in mouse[2].
| Animal Model: | BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2] |
| Dosage: | 40, 80 mg/kg |
| Administration: | P.o.; for 21 days |
| Result: | Inhibited the growth of tumors while unchanged the body weights. |
IC 50
LSD1
References
[1] Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. DOI:10.29219/fnr.v66.8714
[2] Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. DOI:10.1007/s10637-020-01016-y
arborinine Preparation Products And Raw materials
Raw materials
Preparation Products
arborinine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30227 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5645 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 7973 | 60 |
| Shanghai Yu Ben Biotechnology Co., Ltd. | 021-61350663 15502154572 | 1639466865@qq.com | China | 493 | 58 |
| Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 | 3004987436@qq.com | China | 9692 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10343 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24342 | 58 |
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