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1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole structure

CAS No.: 67085-11-4

Chemical Name:: 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole

Synonyms: BUTOCOZOL IMPURITY 2;Butoconazol Impurity 2;Butoconazole Impurity 2;Butoconazole Nitrate INT II;Butoconazole 2-Hydroxy Impurity;1-[4-(4-Chlorophenyl)-2-hydroxylbutyl];4-(4-chlorophenyl)-1-imidazol-1-ylbutan-2-ol;4-(4-Chlorophenyl)-1-(1-imidazolyl)-2-butanol;1-[4-(4-CHLOROPHENYL)-2-HYDROXYLBUTYL]IMIDAZOLE;4-(4-Chlorophenyl)-1-(1H-iMidazol-1-yl)butan-2-ol

CBNumber:: CB81476378

Molecular Formula:: C13H15ClN2O

Molecular Weight:: 250.72

MDL Number:: MFCD09751154

MOL File:: 67085-11-4.mol

MSDS File:: SDS

Last updated:2026-05-28 03:43:03

Product description	Number	Pack Size	Price
Alpha-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol	TRC-C378070-250MG	250mg	$212
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	AA00F9W0	5g	$18
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	AA00F9W0	25g	$74
4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	CD11075272	25g	$91
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	CM187257	25g	$53
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1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Properties

Melting point	106-109 °C(Solv: ethyl acetate (141-78-6))
Boiling point	472.2±40.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO, Methanol (Slightly)
form	Solid
pka	13.69±0.20(Predicted)
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H332-H302-H312
Precautionary statements	P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
REACH Registrations	Active

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-C378070-250MG	Alpha-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol	67085-11-4	250mg	$212	2026-06-03	Buy
aablocks	AA00F9W0	4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	67085-11-4	5g	$18	2026-05-28	Buy
aablocks	AA00F9W0	4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	67085-11-4	25g	$74	2026-05-28	Buy
Crysdot	CD11075272	4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	67085-11-4	25g	$91	2026-05-26	Buy
Chemenu	CM187257	4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol 98%	67085-11-4	25g	$53	2026-05-26	Buy

Product number	Packaging	Price	Buy
TRC-C378070-250MG	250mg	$212	Buy
AA00F9W0	5g	$18	Buy
AA00F9W0	25g	$74	Buy
CD11075272	25g	$91	Buy
CM187257	25g	$53	Buy

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Chemical Properties,Uses,Production

Uses

α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is used as a reactant in the preparation of imidazol phenylbutane derivatives as heme oxygenase inhibitors. α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol is also an impurity of Butoconazole (B690273), which is an antifungal.

Synthesis

288-32-4

59363-13-2

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole

67085-11-4

(2) In a dry DMF solvent, sodium hydride (in the form of mineral oil dispersion) at a concentration of 20% was added and 20 mL of a DMF solution of imidazole was added dropwise at a rate of 2 mL/s under ice bath cooling conditions. Subsequently, the reaction mixture was stirred at 60 °C for 60 min. After the ice bath was cooled, Intermediate 1 (weight ratio of imidazole, sodium hydride to Intermediate 1 was 7:7:5) was slowly added via the salt bath method. The reaction mixture was continued to be stirred at 60°C for 120 minutes. After completion of the reaction, the reaction was again cooled in an ice bath and a 25% n-hexane solution was added to the reaction mixture and stirred at a rate of 3 rev/s for 15 min. Subsequently, ice (350% by weight of the reaction mixture) was added and stirring was continued at a rate of 3 rev/s until the precipitation was complete. The precipitate was collected by filtration and the filter cake was washed once with water and then dried by centrifugation at 2830 r/min for 60 minutes. The resulting product was treated with 2.5 times its weight of ethyl acetate and 0.05 times its weight of activated charcoal, left to stand at 5 °C for 13 h, followed by recrystallization at 50 °C. The yield of Intermediate 2 was 71.5% by HPLC analysis, wherein the purity of the target product 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]imidazole was 99.31%.

References

[1] Patent: CN105218455, 2016, A. Location in patent: Paragraph 0055
[2] Patent: CN105175341, 2017, B. Location in patent: Paragraph 0048-0052
[3] Patent: CN105175338, 2018, B. Location in patent: Paragraph 0069-0071
[4] Patent: CN107501190, 2017, A. Location in patent: Paragraph 0033; 0036; 0043; 0046
[5] Patent: WO2005/70897, 2005, A1. Location in patent: Page/Page column 7

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Preparation Products And Raw materials

Raw materials

Imidazole 1-Chloro-4-(4-chlorophenyl)-2-butanol Sodium hydride N,N-Dimethylformamide

Preparation Products

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole Suppliers

Global( 113)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	877	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
Tianjin Zhongxin Chemtech Co., Ltd.	86-22-66880623 +8618622897568	sales@tjzxchem.com	China	571	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	490	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58

Supplier	Advantage
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
ATK CHEMICAL COMPANY LIMITED	60
Tianjin Zhongxin Chemtech Co., Ltd.	58
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-02-25	1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4		100g	99%	20tons	Hong Kong Tiansheng New Material Trading Co., Ltd
	2019-08-30	1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole 67085-11-4	$1.00	1KG	98%	200kg	Career Henan Chemical Co

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
67085-11-4
$0.99
99%
Hong Kong Tiansheng New Material Trading Co., Ltd

1-[4-(4-Chlorophenyl)-2-hydroxylbutyl]imidazole
67085-11-4
$1.00
98%
Career Henan Chemical Co

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1-[4-(4-CHLOROPHENYL)-2-HYDROXYLBUTYL]IMIDAZOLE 1H-IMIDAZOLE-1-ETHANOL,α-[2-(4-CHLOROPHENYL)ETHYL]-(9CI) 1-[4-(4-Chlorophenyl)-2-hydroxyl-butyl]-1H-imidazole 1-[4-(4-Chlorophenyl)-2-hydroxylbutyl] 4-(4-Chlorophenyl)-1-(1H-iMidazol-1-yl)butan-2-ol Butoconazole Nitrate INT II 1-[4-(4-chlorophenyl)-2-hydroxy-n-butyl]-imidazole 4-(4-chlorophenyl)-1-imidazol-1-ylbutan-2-ol Butoconazole Impurity 2 Butoconazole 2-Hydroxy Impurity 1H-Imidazole-1-ethanol, α-[2-(4-chlorophenyl)ethyl]- α-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol 1-[4-(4-Chlorophenyl)-2-hydroxyl-n-butyl]imidazole Butoconazol Impurity 2 BUTOCOZOL IMPURITY 2 4-(4-Chlorophenyl)-1-(1-imidazolyl)-2-butanol Alpha-[2-(4-Chlorophenyl)ethyl]-1H-imidazole-1-ethanol 67085-11-4