Description
Ac2-26 is an annexin A1-mimetic peptide that corresponds to amino acids 2-26 of the N-terminus in annexin A1.1 It binds to HEK293 cells expressing human formyl peptide receptor 1 (FPR1) or FPR2, also known as FPR-like 1 (FPRL1; EC50s = 1.4 and 1.8 µM, respectively, in a radioligand binding assay), as well as inhibits polymorphonuclear leukocyte (PMN) rolling over TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 30 µM. Ac2-26 (10 and 100 µg/ml) inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nitric oxide (NO) in rat microglial cells.2 It decreases pulmonary edema in a rat model of ventilator-induced ischemia-reperfusion injury when administered at doses of 0.5 and 1 mg/kg.3WARNING This product is not for human or veterinary use.
References
[1] RICHARD P G HAYHOE. Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.[J]. Blood, 2006, 107 5: 2123-2130. DOI: 10.1182/blood-2005-08-3099
[2] L MINGHETTI. Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.[J]. British Journal of Pharmacology, 1999, 126 6: 1307-1314. DOI: 10.1038/sj.bjp.0702423
[3] WEN-I LIAO. Ac2-26, an Annexin A1 Peptide, Attenuates Ischemia-Reperfusion-Induced Acute Lung Injury.[J]. International Journal of Molecular Sciences, 2017, 18 8. DOI: 10.3390/ijms18081771
