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HEMOKININ 1 (HUMAN)

HEMOKININ 1 (HUMAN) structure

CAS No.: 491851-53-7

Chemical Name:: HEMOKININ 1 (HUMAN)

Synonyms: HHK-1;HK-1 (HUMAN);HEK-1 (HUMAN);HEMOKININ 1 (HUMAN);HK-1 (huMan), HEK-1 (huMan);Hemokinin 1 human >=98% (HPLC), solid;Hemokinin 1 (human) trifluoroacetate salt;HeMokinin 1 (huMan) HK-1 (huMan), HEK-1 (huMan);THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2;H-THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2

CBNumber:: CB8281393

Molecular Formula:: C54H84N14O14S

Molecular Weight:: 1185.4

MDL Number:: MFCD06656083

MOL File:: 491851-53-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-22 15:57:46

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HEMOKININ 1 (HUMAN) Properties

storage temp.	−20°C
solubility	Water: soluble
form	solid
color	white
Water Solubility	Soluble to 0.70 mg/ml in water
Sequence	H-Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
InChIKey	NYBLUYYRUFKGTB-XJCFQSCISA-N
UNSPSC Code	12352202
NACRES	NA.32

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
Storage Class	11 - Combustible Solids

HEMOKININ 1 (HUMAN) price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H1664	Hemokinin 1 human ≥98% (HPLC), solid	491851-53-7	1mg	$321	2025-07-31	Buy
Cayman Chemical	35458	Hemokinin 1 (human) (trifluoroacetate salt) ≥98%		1mg	$308	2026-04-30	Buy
Cayman Chemical	35458	Hemokinin 1 (human) (trifluoroacetate salt) ≥98%		5mg	$1078	2026-04-30	Buy
Biosynth	FH109688	Hemokinin 1 (human) trifluoroacetate salt	491851-53-7	1mg	$900	2026-06-04	Buy
Biosynth	FH109688	Hemokinin 1 (human) trifluoroacetate salt	491851-53-7	10mg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
H1664	1mg	$321	Buy
35458	1mg	$308	Buy
35458	5mg	$1078	Buy
FH109688	1mg	$900	Buy
FH109688	10mg	$900	Buy

HEMOKININ 1 (HUMAN) Chemical Properties, Uses, Production

Uses

Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia[1][2].

Biological Activity

Hemokinin 1 (HK1) is an endogenous agonist for all tachykinin receptors. However, it is highly selective for the NK1 (neurokinin 1) receptor. HK1 and substance-P compete with each other for binding to NK1. HK1 is involved in the B-cell as well as T-cell development.', 'NK1 tachykinin receptor agonist.

IC 50

NK1; NK2; NK3

Description

HK1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain fused to a 20 amino acids His tag at the N-terminal encoding the sequence of 937 amino acids and having a molecular mass of 104.6 kDa. HXK1 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli

Background

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase1 encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of HXK1 results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

References

[1] Cai-Yun Fu, et al. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One DOI:10.1371/journal.pone.0090446

[2] Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan;135(1):266-74. DOI:10.1038/sj.bjp.0704443
[3] YIXIN ZHANG . Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptors[J]. Peptides, 2016, 83: Pages 8-15. DOI: 10.1016/j.peptides.2016.07.004

[4] HONGJIN SONG. Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor[J]. International Journal of Biochemistry & Cell Biology, 2012, 44 9: Pages 1410-1421. DOI: 10.1016/j.biocel.2012.04.014

[5] LIYING DAI. Hemokinin-1 stimulates prostaglandin E₂ production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 340 1: 27-36. DOI: 10.1124/jpet.111.186155

[6] CAI Y. FU . In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice[J]. Brain, Behavior, and Immunity, 2008, 22 6: Pages 850-860. DOI: 10.1016/j.bbi.2007.12.010

[7] ZI-QING KONG . Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats[J]. European journal of pharmacology, 2008, 590 1: Pages 310-316. DOI: 10.1016/j.ejphar.2008.05.049

HEMOKININ 1 (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

HEMOKININ 1 (HUMAN) Suppliers

Global Suppliers ( 91)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
Creative Peptides		info@creative-peptides.com	United States	6083	56
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28150	68
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4726	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Cellmano Biotech Limited	55
Creative Peptides	56
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Nanjing Leon Biological Technology Co., Ltd.	55
Nanjing Peptide Biotech Ltd.	55
Chengdu Youngshe Chemical Co., Ltd.	58

View Latest Price from HEMOKININ 1 (HUMAN) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-21	Hemokinin 1, human 491851-53-7	$148.00			10g	TargetMol Chemicals Inc.
	2020-03-06	HEMOKININ 1 (HUMAN) 491851-53-7	$1.00	1g	≥98%		Career Henan Chemical Co

Hemokinin 1, human
491851-53-7
$148.00
TargetMol Chemicals Inc.

HEMOKININ 1 (HUMAN)
491851-53-7
$1.00
≥98%
Career Henan Chemical Co

491851-53-7 (HEMOKININ 1 (HUMAN)) Related Search:

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Anti-Mouse NK1.1 Antibody (PK136)

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H-THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2 HHK-1 HK-1 (HUMAN) HEK-1 (HUMAN) HEMOKININ 1 (HUMAN) THR-GLY-LYS-ALA-SER-GLN-PHE-PHE-GLY-LEU-MET-NH2 HeMokinin 1 (huMan) HK-1 (huMan), HEK-1 (huMan) HK-1 (huMan), HEK-1 (huMan) (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]acetyl]amino]hexanoyl]amino]propanoyl]amino]-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide Hemokinin 1 (human) trifluoroacetate salt L-Methioninamide, L-threonylglycyl-L-lysyl-L-alanyl-L-seryl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- Hemokinin 1 human >=98% (HPLC), solid 491851-53-7 C54H82N14O14S C54H84N14O14S